Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-5207852 dihydrochloride is a novel, non-imidazole histamine H3 receptor antagonist with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
2 mg | In stock | $ 72.00 | |
5 mg | In stock | $ 103.00 | |
10 mg | In stock | $ 181.00 | |
25 mg | In stock | $ 363.00 | |
50 mg | In stock | $ 539.00 | |
100 mg | In stock | $ 778.00 | |
500 mg | In stock | $ 1,620.00 |
Description | JNJ-5207852 dihydrochloride is a novel, non-imidazole histamine H3 receptor antagonist with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor. |
In vivo | JNJ-5207852 is a potent dibasic amine antagonist that binds potently to rat H3 receptors (Ki=1.2?nm), and has good brain penetration. In ex vivo binding studies in mice, the compound had an ED50 of 0.13?mg?kg?1, subcutaneously. It promotes wakefulness in rodents at 10?mg?kg?1 s.c. but not at 1?mg?kg?1, and significantly, this effect was absent in H3 receptor KO mice. JNJ-10181457 is also a dibasic amine antagonist that exhibits high-affinity binding for the rat H3 receptor (Ki=7.1?nm), promoting wakefulness in rodents and reducing cataplectic attacks in narcoleptic dogs . JNJ-10181457 improved cognitive performance in SHR pups at 10?mg?kg?1[1]. |
Molecular Weight | 389.4 |
Formula | C20H34Cl2N2O |
CAS No. | 1782228-76-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
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JNJ-5207852 dihydrochloride 1782228-76-5 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor Inhibitor JNJ-5207852 toxicity inhibit JNJ5207852 JNJ 5207852 JNJ 5207852 Dihydrochloride low sleep JNJ5207852 Dihydrochloride REM JNJ5207852 dihydrochloride JNJ-5207852 Dihydrochloride JNJ 5207852 dihydrochloride inhibitor