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Hu7691 free base

Catalog No. T39733 CAS 2241232-43-7

Hu7691 free base is an orally active, potent and selective Akt inhibitor with anti-proliferative and neurogenic effects on a variety of neuroblastoma cell lines.Hu7691 free base inhibits Akt1, Akt2, and Akt3 and induces differentiation of neuroblastoma cells.

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Hu7691 free base, CAS 2241232-43-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 293.00
5 mg	In stock	$ 722.00
10 mg	In stock	$ 987.00
25 mg	In stock	$ 1,520.00
50 mg	In stock	$ 1,980.00

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Purity: 98.89%

ee: 97.96%

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Description	Hu7691 free base is an orally active, potent and selective Akt inhibitor with anti-proliferative and neurogenic effects on a variety of neuroblastoma cell lines.Hu7691 free base inhibits Akt1, Akt2, and Akt3 and induces differentiation of neuroblastoma cells.
Targets&IC50	PKCη:629 nM (IC50), Akt3:28 nM (IC50), ROCK1:354 nM (IC50), p70 S6K:229 nM (IC50), PKA:11 nM (IC50), Akt2:97.5 nM (IC50), Akt1:4.0 nM (IC50), RSK1:756 nM (IC50), AKT1:4.0 nM, AKT2:97.5 nM, AKT3:28 nM, mTOR (p70S6K):229 nM, PKA:11 nM, PKCη:629 nM, ROCK1:354 nM, RSK1:756 nM
In vitro	In HaCaT cells, Hu7691 free base (2.25, 4.5, 9, 18, 36 μM; 24 hours) effectively induces a decrease in the phosphorylation level of Akt (S473)[1].
In vivo	In Balb/c mice (nu/nu, female, 3-4 weeks old, 20-25 g), Hu7691 free base (12.5, 25, 50 mg/kg; oral; once daily for 22 days) exhibited dose-dependent inhibition of tumor growth[1].

Molecular Weight	414.423
Formula	C22H21F3N4O
CAS No.	2241232-43-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jinxin Che, et al. Discovery of N-((3 S,4 S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1 H-pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity. J Med Chem. 2021 Aug 26;64(16):1

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Keywords

Hu7691 free base 2241232-43-7 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Akt Hu-7691 free base Hu7691 inhibitor inhibit

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