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Artemisinin

Catalog No. T0392   CAS 63968-64-9
Synonyms: Qinghaosu,Artemisinine, Qinghaosu, NSC 369397, Artemisinine

Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organisms, including chloroquine-resistant Plasmodium falciparum.

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Artemisinin Chemical Structure
Artemisinin, CAS 63968-64-9
Pack Size Availability Price/USD Quantity
200 mg In stock $ 58.00
500 mg In stock $ 83.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 100%
Purity: 99.77%
Purity: 97%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organisms, including chloroquine-resistant Plasmodium falciparum.
In vivo Artemisinin (50, 100 or 200 mg/kg b.wt/day, p.o.) prevents isoflurane-induced working memory impairments as observed in T-maze test. Artemisinin enhances spatial navigation and memory of rats exposed to isoflurane. Artemisinin-treated rats exhibit markedly better performance in comparison with isoflurane-alone-exposed rats[4].
Kinase Assay Briefly, PC12 cells are lysed in lysis buffer and centrifuged at 12,500×g for 5 min 15 mL of cell lysate is incubated with 50 mL of 2X substrate working solution at room temperature for 30 min in 96-well plates. The fluorescence intensity is then determined by Infinite M200 PRO Multimode Microplate at an excitation wavelength of 490 nm and emission at 520 nm. The fluorescence intensity of each sample is normalized to the protein concentration of sample. All values of % caspase 3/7 activities are normalized to the control group.
Cell Research Artemisinin is diluted in 0.01% DMSO. For this purpose, cells are cultivated in 96-well plates in DMEM, supplemented with insulin. The artemisinin, Dox, and DDP are added to media at different concentrations and the cells are cultivated for either 24 or 48 h. For this purpose artemisinin is diluted in 0.01% DMSO in media. After this time, 10 μL of the MTT dye solution (5 mg/mL in phosphate buffer saline) is added to the cells; the cells are incubated at the same conditions for 3 h. After centrifugation (1500 rpm, 5 min) the supernatant is removed. 100 μL of dimethyl sulfoxide is added to each well, to dissolve formazan. The absorption is measured, using a multi-well spectrophotometer at a wavelength of 540 nm.
Source
Synonyms Qinghaosu,Artemisinine, Qinghaosu, NSC 369397, Artemisinine
Molecular Weight 282.33
Formula C15H22O5
CAS No. 63968-64-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 28.2 mg/mL (100 mM)

Ethanol: 21.2 mg/mL (75 mM)

TargetMolReferences and Literature

1. Meshnick SR, et al. Mol Biochem Parasitol,1991, 49(2), 181-189. 2. Eastman RT, et al. Nat Rev Microbiol,2009, 7(12), 864-874. 3. O'Neill PM, et al. Molecules,2010, 15(3), 1705-1721. 4. Xu G, et al. Neuroprotective effects of artemisinin against isoflurane-induced cognitive impairments and neuronal cell death involve JNK/ERK1/2 signalling and improved hippocampal histone acetylation in neonatal rats. J Pharm Pharmacol. 2017 Mar 12. 6. Lin SP, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108.

TargetMolCitations

1. Liu Y, Li H, Luo Z, et al. Artesunate, a new antimalarial clinical drug, exhibits potent anti‐AML activity by targeting the ROS/Bim and TFRC/Fe2+ pathways. British Journal of Pharmacology. 2022

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Parasitic Compound Library Anti-Cancer Clinical Compound Library Antiparasitic Natural Product Library Anti-Cancer Approved Drug Library Drug-Fragment Library Natural Product Library Stem Cell Differentiation Compound Library Anti-Prostate Cancer Compound Library

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Keywords

Artemisinin 63968-64-9 Apoptosis Cytoskeletal Signaling Microbiology/Virology PI3K/Akt/mTOR signaling Proteases/Proteasome Akt Parasite HCV Protease Ferroptosis Qinghaosu,Artemisinine Qinghaosu Hepatitis C virus NSC-369397 Inhibitor inhibit Protein kinase B HCV NSC 369397 PKB NSC369397 Artemisinine inhibitor

 

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