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Microbiology/Virology HCV Protease Artemisinin

Artemisinin

Catalog No. T0392   CAS 63968-64-9
Synonyms: NSC 369397, Qinghaosu, Qinghaosu,Artemisinine, Artemisinine

Artemisinin is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organisms, including chloroquine-resistant Plasmodium falciparum.

Artemisinin, CAS 63968-64-9
Pack Size Availability Price/USD Quantity
100 mg In stock 50.00
200 mg In stock 69.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Purity 100.00%
Purity 99.77%
Purity 97.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Artemisinin is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organisms, including chloroquine-resistant Plasmodium falciparum.
Targets&IC50 Others
In vivo Artemisinin (50, 100 or 200 mg/kg b.wt/day, p.o.) prevents isoflurane-induced working memory impairments as observed in T-maze test. Artemisinin enhances spatial navigation and memory of rats exposed to isoflurane. Artemisinin-treated rats exhibit markedly better performance in comparison with isoflurane-alone-exposed rats[4].
Kinase Assay Briefly, PC12 cells are lysed in lysis buffer and centrifuged at 12,500×g for 5 min 15 mL of cell lysate is incubated with 50 mL of 2X substrate working solution at room temperature for 30 min in 96-well plates. The fluorescence intensity is then determined by Infinite M200 PRO Multimode Microplate at an excitation wavelength of 490 nm and emission at 520 nm. The fluorescence intensity of each sample is normalized to the protein concentration of sample. All values of % caspase 3/7 activities are normalized to the control group.
Cell Research
Artemisinin is diluted in 0.01% DMSO. For this purpose, cells are cultivated in 96-well plates in DMEM, supplemented with insulin. The artemisinin, Dox, and DDP are added to media at different concentrations and the cells are cultivated for either 24 or 48 h. For this purpose artemisinin is diluted in 0.01% DMSO in media. After this time, 10 µL of the MTT dye solution (5 mg/mL in phosphate buffer saline) is added to the cells; the cells are incubated at the same conditions for 3 h. After centrifugation (1500 rpm, 5 min) the supernatant is removed. 100 μL of dimethyl sulfoxide is added to each well, to dissolve formazan. The absorption is measured, using a multi-well spectrophotometer at a wavelength of 540 nm.
Synonyms NSC 369397 , Qinghaosu , Qinghaosu,Artemisinine , Artemisinine
Purity 100.00%
Molecular Weight 282.33
Formula C15H22O5
CAS No. 63968-64-9

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 28.2 mg/mL (100 mM)

Ethanol: 21.2 mg/mL (75 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Meshnick SR, et al. Mol Biochem Parasitol,1991, 49(2), 181-189. 2. Eastman RT, et al. Nat Rev Microbiol,2009, 7(12), 864-874. 3. O'Neill PM, et al. Molecules,2010, 15(3), 1705-1721. 4. Xu G, et al. Neuroprotective effects of artemisinin against isoflurane-induced cognitive impairments and neuronal cell death involve JNK/ERK1/2 signalling and improved hippocampal histone acetylation in neonatal rats. J Pharm Pharmacol. 2017 Mar 12. 6. Lin SP, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108.

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Approved Drug Library Bioactive Compound Library Natural Compound Library for HTS Anti-cancer Compound Library Clinical Compound Library Anti-infection Compound Library Apoptosis Compound Library Autophagy Compound Library Neuronal Signaling Compound Library Anti-virus Compound Library Immunology/Inflammation Compound Library Selected Plant-sourced Compound Library Kinase Inhibitor Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Anti-cancer Metabolism Compound Library CNS-Penetrant Compound Library Anti-aging Compound Library Antitumor Natural Products Library Natural Compoud Library in Chinese Pharmacopoeia Anti-cancer Drug library Drug Repurposing Library Ferroptosis Compound Library Anti-COVID-19 Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Drug-induced Liver Injury (DILI) Compound Library NMPA-Approved Drug Library FDA Approved & Pharmacopeial Drug Library Traditional Chinese Medicine Monomer Library Anti-Breast Cancer Compound Library Glutamine Metabolism Compound Library

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