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HTHQ

Catalog No. T3647 CAS 148081-72-5

Synonyms: HX 1171, HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone), 1-O-hexyl-2,3,5-trimethylhydroquinone

HTHQ (HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)), a hydroquinone monoalkyl ether, is an effective anti-oxidative agent. HTHQ is a potent anti-lipid-peroxidative compound and its antioxidation activity to be extremely elevated in biological systems, such as that of liver microsomes via the generation of stable free radicals.

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HTHQ, CAS 148081-72-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 47.00
25 mg	In stock	$ 61.00
50 mg	In stock	$ 77.00
100 mg	In stock	$ 97.00
200 mg	In stock	$ 158.00
1 mL * 10 mM (in DMSO)	In stock	$ 42.00

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Purity: 99.81%

Purity: 99.79%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HTHQ (HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)), a hydroquinone monoalkyl ether, is an effective anti-oxidative agent. HTHQ is a potent anti-lipid-peroxidative compound and its antioxidation activity to be extremely elevated in biological systems, such as that of liver microsomes via the generation of stable free radicals.
In vitro	HTHQ has an anti-oxidative activity similar to D,L-alpha-tocopherol against lipid peroxidation in linolate micelles initiated by addition of Fe2+. The anti-lipid-peroxidation activity of HTHQ is higher 4.8-fold than that of D,L-alpha-tocopherol against the peroxidation in phosphatidylcholine liposomes initiated by addition of Fe2+. [1] The effects of 0.02% Glu-P-1 or 0.03% MeIQx on the number and area of foci is significantly reduced by 0.125% HTHQ. [2]
In vivo	Treatment with HTHQ potently inhibits PhIP-induced mammary carcinogenesis in female rats. Compared with DMN-induced hepatic fibrosis animals in the liver tissue, HTHQ reduced mRNA level of PDGF (Platelet-derived growth factor), α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β). In this study, we showed that HTHQ improves against DMN-induced liver fibrosis in male SD rats.

Synonyms	HX 1171, HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone), 1-O-hexyl-2,3,5-trimethylhydroquinone
Molecular Weight	236.35
Formula	C15H24O2
CAS No.	148081-72-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 43 mg/mL(181.9 mM)

References and Literature

1. Hirose M, et al. Carcinogenesis. 1995 Dec;16(12):3049-55. 2. Hino T, et al. Biochim Biophys Acta. 1998 Sep 16;1425(1):47-60.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library NF-κB Signaling Compound Library ReFRAME Related Library Anti-Prostate Cancer Compound Library Anti-Obesity Compound Library Pyroptosis Compound Library Metabolism Compound Library Antioxidant Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

HTHQ 148081-72-5 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species HX 1171 BTT 105 BTT105 inhibit BTT-105 HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone) HX-1171 1-O-hexyl-2,3,5-trimethylhydroquinone Inhibitor HX1171 inhibitor

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