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HTH-01-091

Catalog No. T24152 CAS 2000209-42-5

Synonyms: HTH-01091, HTH01-091, HTH 01-091, HTH 01091

HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be used to study breast cancer.

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HTH-01-091, CAS 2000209-42-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 296.00
2 mg	In stock	$ 448.00
5 mg	In stock	$ 728.00
10 mg	In stock	$ 1,130.00
25 mg	In stock	$ 1,590.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00
1 mL * 10 mM (in DMSO)	In stock	$ 823.00

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Purity: 98.40%

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Description	HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be used to study breast cancer.
Targets&IC50	mTOR:632 nM, CDK7:1230 nM, DYRK4:41.8 nM, Pim1:60.6 nM
In vitro	HTH-01-091 (0-10 μM, 1 h) dose-dependently decreased MELK pull-down by streptavidin beads, demonstrating that the compound is cell permeable and binds to MELK in an ATP-competitive fashion causes MELK degradation.[1] HTH-01-091 (1 μM) selectively inhibits 4% of the kinases over 90%[1]. HTH-01-091 (0-10 μM, 3 days) exhibits minor antiproliferative effects in breast cancer cells[1].

Synonyms	HTH-01091, HTH01-091, HTH 01-091, HTH 01091
Molecular Weight	499.43
Formula	C26H28Cl2N4O2
CAS No.	2000209-42-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (10 mM)

References and Literature

1. Huang HT, et al. MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife. 2017;6:e26693. 2. McDonald IM, et al. Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells. J Biol Chem. 2020;295(8):2359-2374.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Inhibitor Library Anti-Cancer Compound Library Anti-Obesity Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HTH-01-091 2000209-42-5 Apoptosis Cell Cycle/Checkpoint Chromatin/Epigenetic JAK/STAT signaling Metabolism NF-Κb PI3K/Akt/mTOR signaling Tyrosine Kinase/Adaptors CDK RIP kinase Serine/threonin kinase DYRK Pim MELK HTH01091 HTH-01091 HTH01-091 HTH 01-091 HTH 01091 inhibitor inhibit

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