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HJC0350

Catalog No. T6536   CAS 885434-70-8

HJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 μM), and no inhibition of Epac1.

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HJC0350 Chemical Structure
HJC0350, CAS 885434-70-8
Pack Size Availability Price/USD Quantity
5 mg In stock $ 47.00
10 mg In stock $ 64.00
25 mg In stock $ 139.00
50 mg In stock $ 228.00
100 mg In stock $ 393.00
200 mg In stock $ 585.00
500 mg In stock $ 937.00
1 mL * 10 mM (in DMSO) In stock $ 52.00
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Purity: 99.53%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description HJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 μM), and no inhibition of Epac1.
Targets&IC50 EPAC2:0.3 μM
In vitro HJC0350 selectively blocks cAMP-induced EPAC2 activation but do not inhibit cAMP-mediated PKA activation. In HEK293/EPAC2-FL cells, HJC0350 also inhibits 007-AM mediated cellular activation of EPAC2. [1]
Kinase Assay In Vitro IRE1 RNase and RIDD Assays: Analysis of radiolabeled Xbp1 substrate cleavage is performed as previously except that mammalian IRE1 reaction buffer is used. In vitro RIDD substrates are synthesized by in vitro transcription using the T7-MAXIscript Kit in the presence of 32P ATP or Cy5-UTP on templates isolated by RT-PCR from mouse Min6 cells (Ins2) or PCR from cloned XBP1 cDNA. The resulting products are gel purified to obtain full-length substrate. Reactions are then separated by 15% UREA-PAGE for analysis by phosphorimaging or by near-infrared imaging using the LI-COR Odyssey scanner.
Molecular Weight 277.38
Formula C15H19NO2S
CAS No. 885434-70-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 13.9 mg/mL (50 mM)

Ethanol: 5.6 mg/mL (20 mM)

TargetMolReferences and Literature

1. Chen H, et al. J Med Chem. 2013, 56(3), 952-962.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library GPCR Compound Library Inhibitor Library Bioactive Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Target-Focused Phenotypic Screening Library

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Keywords

HJC0350 885434-70-8 GPCR/G Protein cAMP inhibit Inhibitor HJC-0350 HJC 0350 inhibitor

 

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