Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 115.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 413.00 | |
25 mg | In stock | $ 692.00 | |
50 mg | In stock | $ 985.00 | |
100 mg | In stock | $ 1,330.00 | |
500 mg | In stock | $ 2,660.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 272.00 |
Description | H3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity. |
Targets&IC50 | CPS1:1.4 μM (ki), CPS1:1.5 μM |
In vitro | H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays. The half-life of H3B-120 is only 40 min. H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase). |
Molecular Weight | 372.48 |
Formula | C19H24N4O2S |
CAS No. | 2194903-42-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62 mg/mL (166.45 mM)
You can also refer to dose conversion for different animals. More
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H3B-120 2194903-42-7 Membrane transporter/Ion channel Others Potassium Channel KcsA H3B 120 carbamoyl H3B120 inhibit Inhibitor anti-cancer phosphate synthetase CPS1 H-3B-120 inhibitor