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Glycol chitosan

Catalog No. T13708 CAS 123938-86-3

Glycol chitosan is a chitosan derivative with hydrophilic ethylene glycol branches. Glycol chitosan inhibits E. coli, S. aureus, and S. enteritidis growths (MICs: 4 μg/mL, 32 μg/mL, and <0.5 μg/mL). It enhances membrane permeability and leakage in Glycine max Harosoy 63W cells.

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Glycol chitosan, CAS 123938-86-3

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Purity: 60%

Biological Description

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Storage & Solubility Information

Description	Glycol chitosan is a chitosan derivative with hydrophilic ethylene glycol branches. Glycol chitosan inhibits E. coli, S. aureus, and S. enteritidis growths (MICs: 4 μg/mL, 32 μg/mL, and <0.5 μg/mL). It enhances membrane permeability and leakage in Glycine max Harosoy 63W cells.
Targets&IC50	S. aureus: 32 μg/mL , E. coli:(MIC)4 μg/mL , S. enteritidis:<0.5 μg/mL
In vitro	The hydrophobic modification of Glycol chitosan has been validated, with derivatives such as Glycol chitosan with a 5β-cholanic acid moiety and deoxycholic acid-Glycol chitosan, capable of self-assembling into nanoparticles, demonstrating potential as carriers for hydrophobic drugs and genes [2]. Glycol chitosan can be covalently bonded with hydrophobic drugs to create amphiphilic compounds that form nanoparticles (NPs) useful in cell imaging and drug delivery. These derivatives are effectively utilized to transport antimicrobial and anticancer agents, employing either physical encapsulation or chemical conjugation methods. Glycol chitosan derivatives are advantageous for cell imaging and drug delivery due to their exceptional tumor-targeting capabilities stemming from the enhanced permeability and retention (EPR) effect, minimal cytotoxicity, chemical modifiability, high biocompatibility, and degradability [1].

Molecular Weight	N/A
CAS No.	123938-86-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 7.5 mg/mL, Sonication is recommended.

DMSO: 11.67 mg/mL, Sonication is recommended.

References and Literature

1. Lin F, et al. Glycol Chitosan: A Water-Soluble Polymer for Cell Imaging and Drug Delivery. Molecules. 2019 Nov 29;24(23). pii: E4371. 2. Yu A, et al. Mucoadhesive dexamethasone-glycol chitosan nanoparticles for ophthalmic drug delivery. Int J Pharm. 2020 Feb 15;575:118943. 3. Young DH, et al. Effect of Chitosan on Membrane Permeability of Suspension-Cultured Glycine max and Phaseolus vulgaris Cells. Plant Physiol. 1982 Nov;70(5):1449-54. 4. Stephen Inbaraj B, et al.Synthesis, characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan.Sci Technol Adv Mater. 2012 Feb 2;13(1):015002.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Glycol chitosan 123938-86-3 Microbiology/Virology Antibacterial inhibit Inhibitor Bacterial inhibitor

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