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Angiogenesis EGFR Genistein

Genistein

Catalog No. T1737   CAS 446-72-0
Synonyms: NPI 031L

Genistein is an isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA TOPOISOMERASES, TYPE II), with antineoplastic and antitumor activities.

Genistein, CAS 446-72-0
Pack Size Availability Price/USD Quantity
5 mg In stock 18.00
10 mg In stock 25.00
50 mg In stock 42.00
100 mg In stock 55.00
500 mg In stock 100.00
1 mL * 10 mM (in DMSO) In stock 18.00
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Purity 99.69%
Purity 98.22%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Genistein is an isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA TOPOISOMERASES, TYPE II), with antineoplastic and antitumor activities.
Targets&IC50 EGFR
Cell Research
Genistein is dissolved in DMSO and stored, and then diluted with appropriate medium before use[1]. The IC50 values for Genistein are determined by the MTT assay. Briefly, the MTT assay is a colorimetric assay that is based on the ability of living but not dead cells to reduce a tetrazolium-based compound to a blue formazan product. The formazan crystals are solubilized in DMSO, and the absorbance is measured at 540 nm. The absorbance at 540 nm is proportional to the number of viable cells. The lC50 values obtained with the MTT assay are compared with the lC50 values obtained by counting viable cells using trypan blue dye exclusion and by tritiated thymidine incorporation into DNA[1].
Synonyms NPI 031L
Purity 99.69%
Molecular Weight 270.24
Formula C15H10O5
CAS No. 446-72-0

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

Ethanol: 2 mg/mL (7.4 mM)

DMSO: 54 mg/mL (199.82 mM)

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Akiyama T, et al. J Biol Chem, 1987, 262(12), 5592-5595. 2. Linassier C, et al. Biochem Pharmacol, 1990, 39(1), 187-193. 3. Dang ZC, et al. J Biol Chem, 2003, 278(2), 962-967. 4. Lamartiniere CA, et al. J Nutr, 2002, 132(3), 552S-558S. 5. Wang Y, et al. Radiat Res, 2006, 166(1 Pt 1), 73-80. 6. Jalili C, et al. Effect of Genistein on reproductive parameter and serum nitric oxide levels in morphine-treated mice. Int J Reprod Biomed (Yazd). 2016 Feb;14(2):95-102. 7. Ding S, et al. Environmentally Relevant Dose of Bisphenol A Does Not Affect Lipid Metabolism and Has No Synergetic or Antagonistic Effects on Genistein's Beneficial Roles on Lipid Metabolism. PLoS One. 2016 May 12;11(5):e0155352. 8. Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT[J]. Oncology Reports. 2021, 45(4): 1-1.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library Clinical Compound Library Stem cell Differentiation Compound Library Apoptosis Compound Library Autophagy Compound Library Human Endogenous Metabolite Compound Library Tyrosine kinase inhibitor library Immunology/Inflammation Compound Library Selected Plant-sourced Compound Library DNA Damage & Repair Compound Library Cytokine Inhibitor Library Kinase Inhibitor Library Bioactive Lipid Compound Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Polyphenolic Natural Compound Library Angiogenesis related Compound Library JAK STAT Compound Library CNS-Penetrant Compound Library Food as Medicine Library Anti-aging Compound Library Antitumor Natural Products Library Natural Compoud Library in Chinese Pharmacopoeia Anti-cancer Active Compound library Anti-cancer Drug library Drug Repurposing Library Anti-Inflammatory Tradition Chinese Medicine Library Flavonoids natural compound library Anti-Lung Cancer Compound Library FDA Approved & Pharmacopeial Drug Library Traditional Chinese Medicine Monomer Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Anti-fibrosis Compound Library

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