Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is a potent serotonin A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 139.00 | |
5 mg | In stock | $ 425.00 | |
10 mg | In stock | $ 618.00 | |
25 mg | In stock | $ 962.00 | |
50 mg | In stock | $ 1,290.00 | |
100 mg | In stock | $ 1,750.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 395.00 |
Description | Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is a potent serotonin A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan |
In vitro | To find the candidate ingredients, we examined competitive binding assay and [(35)S] guanosine 5'-O-(3-thiotriphosphate) (GTPγS) binding assay of seven major alkaloids in UH using Chinese hamster ovary cells expressing 5-HT(1A) receptors artificially. Only Geissoschizine methyl ether (GM) among seven alkaloids potently bound to 5-HT(1A) receptors and acted as a partial agonist. This in vitro result on GM was further demonstrated in the socially isolated mice. As did YKS and UH, GM ameliorated the isolation-induced increased aggressiveness and decreased sociality, and the effect was counteracted by coadministration of WAY-100635[1] |
Source |
Molecular Weight | 366.45 |
Formula | C22H26N2O3 |
CAS No. | 60314-89-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (30.02 mM)
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Geissoschizine methyl ether 60314-89-8 GPCR/G Protein Neuroscience 5-HT Receptor Inhibitor inhibit 5-hydroxytryptamine Receptor Serotonin Receptor inhibitor