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Garcinol

Catalog No. T11366   CAS 78824-30-3

Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively.

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Garcinol Chemical Structure
Garcinol, CAS 78824-30-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 64.00
5 mg In stock $ 193.00
10 mg In stock $ 292.00
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1 mL * 10 mM (in DMSO) In stock $ 273.00
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Purity: 98.59%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively.
Targets&IC50 BChE:7.39 µM , AChE:0.66 µM
In vitro Garcinol (10-50 μM; 24-72 hours) induces apoptosis in HNSCC cells. ?Garcinol (50 μM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.Garcinol (10-50 μM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner.
In vivo Garcinol?induces significant inhibition of tumor growth.
Molecular Weight 602.8
Formula C38H50O6
CAS No. 78824-30-3

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 20 mg/mL (33.18 mM), sonification/heating is recommended.

DMSO: 20 mg/mL (33.18 mM), sonification/heating is recommended.

TargetMolReferences and Literature

1. Lenta BN, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules. 2007 Jul 20;12(8):1548-57. 2. Ciochina R, et al. Polycyclic polyprenylated acylphloroglucinols. Chem Rev. 2006 Sep;106(9):3963-86. 3. Li F, et al. Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signalingcascades leading to the suppression of growth and survival of head and neck carcinoma. Cancer Prev Res (Phila). 2013 Aug;6(8):843-54.

Related compound libraries

This product is contained In the following compound libraries:
Rare Natural Compound Library

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Keywords

Garcinol 78824-30-3 Apoptosis Chromatin/Epigenetic Metabolism Neuroscience Endogenous Metabolite Histone Acetyltransferase AChR AChE Inhibitor HATs PCAF anti-cancer indica anti-inflammatory inhibit HAT Cholinesterase (ChE) BChE Garcinia anti-cholinesterase inhibitor

 

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