store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
5 mg | In stock | $ 193.00 | |
10 mg | In stock | $ 292.00 | |
25 mg | In stock | Inquiry | |
50 mg | Inquiry | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 273.00 |
Description | Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively. |
Targets&IC50 | BChE:7.39 µM , AChE:0.66 µM |
In vitro | Garcinol (10-50 μM; 24-72 hours) induces apoptosis in HNSCC cells. ?Garcinol (50 μM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.Garcinol (10-50 μM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner. |
In vivo | Garcinol?induces significant inhibition of tumor growth. |
Molecular Weight | 602.8 |
Formula | C38H50O6 |
CAS No. | 78824-30-3 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 20 mg/mL (33.18 mM), sonification/heating is recommended.
DMSO: 20 mg/mL (33.18 mM), sonification/heating is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Garcinol 78824-30-3 Apoptosis Chromatin/Epigenetic Metabolism Neuroscience Endogenous Metabolite Histone Acetyltransferase AChR AChE Inhibitor HATs PCAF anti-cancer indica anti-inflammatory inhibit HAT Cholinesterase (ChE) BChE Garcinia anti-cholinesterase inhibitor