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Garcinol

Catalog No. T11366 CAS 78824-30-3

Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively.

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Garcinol, CAS 78824-30-3

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively.
Targets&IC50	BChE:7.39 µM , AChE:0.66 µM
In vitro	Garcinol (10-50 μM; 24-72 hours) induces apoptosis in HNSCC cells. ?Garcinol (50 μM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.Garcinol (10-50 μM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner.
In vivo	Garcinol?induces significant inhibition of tumor growth.

Molecular Weight	602.8
Formula	C38H50O6
CAS No.	78824-30-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 20 mg/mL (33.18 mM), Need ultrasonic and warming

DMSO: 20 mg/mL (33.18 mM), Need ultrasonic and warming

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Lenta BN, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules. 2007 Jul 20;12(8):1548-57. 2. Ciochina R, et al. Polycyclic polyprenylated acylphloroglucinols. Chem Rev. 2006 Sep;106(9):3963-86. 3. Li F, et al. Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signalingcascades leading to the suppression of growth and survival of head and neck carcinoma. Cancer Prev Res (Phila). 2013 Aug;6(8):843-54.

Related Products

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Methyl tridecanoate Vincosamide Arjunolic acid Epiberberine chloride AChE-IN-26 AChE/BChE-IN-10 Jatrorrhizine chloride 1-Naphthyl acetate

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Keywords

Garcinol 78824-30-3 表观遗传代谢凋亡神经科学 AChE AChR Apoptosis Endogenous Metabolite Histone Acetyltransferase Inhibitor HATs PCAF anti-cancer indica anti-inflammatory inhibit HAT Cholinesterase (ChE) BChE Garcinia anti-cholinesterase inhibitor

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