Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GR 46611 is a selective 5-HT1B and 5-HT1D receptor agonist and can be used in studies about the treatment of epilepsy.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 84.00 | |
10 mg | In stock | $ 137.00 | |
25 mg | In stock | $ 278.00 | |
50 mg | In stock | $ 443.00 | |
100 mg | In stock | $ 646.00 |
Description | GR 46611 is a selective 5-HT1B and 5-HT1D receptor agonist and can be used in studies about the treatment of epilepsy. |
In vivo | GR 46611 (0.6 and 6 nmol; paraventricular hypothalamic nucleus (PVN)) promptly and reliably elicited feeding at their higher doses, without affecting drinking or non-ingestive behaviors. GR 46611 (6 nmol) elicited intense feeding responses in the n. medialis hypothalami posterioris and in the adjacent n. lateralis hypothalami posterioris (PMH/PLH complex, in the caudoventral hypothalamus) and in the n. magnocellularis preopticus (PPM, in the caudal preoptic region)[1]. GR 46611 (1 mg/kg) significantly increased the threshold of hyperthermia-induced seizure and lowered seizure severity thereby improving the survival of DS mice[2]. |
Molecular Weight | 377.48 |
Formula | C23H27N3O2 |
CAS No. | 185259-85-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11.3 mg/mL (30 mM)
Ethanol: 10 mM
You can also refer to dose conversion for different animals. More
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GR 46611 185259-85-2 GPCR/G Protein Neuroscience 5-HT Receptor GR-46611 GR46611 inhibitor inhibit