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Fuziline

Name: Fuziline
Brand: TargetMol
SKU: T3S0631
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3S0631Cas No. 80665-72-1

Fuziline is a diterpene alkaloid found in Aconitum kusnezoffii and Aconitum carmichaelii.It is functionally related to an aconitane.

Fuziline

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Purity: 99.96%

Catalog No. T3S0631Cas No. 80665-72-1

Fuziline is a diterpene alkaloid found in Aconitum kusnezoffii and Aconitum carmichaelii.It is functionally related to an aconitane.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$37	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$94	In Stock	In Stock
25 mg	$157	In Stock	In Stock
50 mg	$232	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$76	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.96%

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COA

Product Introduction

Bioactivity

Description	Fuziline is a diterpene alkaloid found in Aconitum kusnezoffii and Aconitum carmichaelii.It is functionally related to an aconitane.
In vitro	In the in vitro assays,fuziline increases cell viability in the model of ISO‐induced injury.
Cell Research	Rat cardiomyocytes(H9c2）were cultured in 96-well plates with High‐glucose DMEM added with 10% FBS,100 μg/mL streptomycin and 100 U/mL penicillin,and H9c2 cells were placed in an incubator with 37°C and 5% CO2 for 24 hours. then addressed with isoproterenol(ISO) and different concentrations of fuziline for the indicated time. Then, the DMEM was removed and 100 μL MTT solution (0.1 mg/well) was added, and H9c2 cells were incubated for 3 hours. After that, the supernatant was removed and the formazan crystals were dissolved in 150 μL DMSO. Then, the absorbance of each sample was detected at 490 nm by a microplate reader.[2]

Chemical Properties

Molecular Weight	453.57
Formula	C₂₄H₃₉NO₇
Cas No.	80665-72-1
Smiles	[H][C@]12C[C@]3([H])[C@]([H])([C@H]1O)[C@@](O)(C1[C@H](OC)[C@@]4([H])C33C1N(CC)C[C@]4(COC)CC[C@@H]3O)[C@@H](O)[C@@H]2OC
Relative Density.	1.36g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (110.24 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2047 mL	11.0237 mL	22.0473 mL	110.2366 mL
5 mM	0.4409 mL	2.2047 mL	4.4095 mL	22.0473 mL
10 mM	0.2205 mL	1.1024 mL	2.2047 mL	11.0237 mL
20 mM	0.1102 mL	0.5512 mL	1.1024 mL	5.5118 mL
50 mM	0.0441 mL	0.2205 mL	0.4409 mL	2.2047 mL
100 mM	0.0220 mL	0.1102 mL	0.2205 mL	1.1024 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc