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Fumaric acid
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Catalog No. T3763Cas No. 110-17-8
Alias Trans-Butenedioic acid, Lichenic acid, Fumarate, Donitic acid, Allomaleic acid, 2-Butenedioic acid
Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes.
Fumaric acid
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Purity: 98.80%
Catalog No. T3763Alias Trans-Butenedioic acid, Lichenic acid, Fumarate, Donitic acid, Allomaleic acid, 2-Butenedioic acidCas No. 110-17-8
Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 g | $32 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.80%
Appearance:Solid
Color:White
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Product Introduction
Fumaric acid AI Summary
Fumaric acid is a multifaceted chemical that exhibits a broad range of bioactivities. In the context of Xenopus oocytes, it inhibits the Oat1-mediated [3H]PAH uptake with Ki values around 616,000 nM, while showing very weak inhibition of Oat6-mediated [3H]ES uptake with Ki values exceeding 31,622,776 nM. Additionally, it impacts 2-oxoglutarate-dependent human JMJD2E and human recombinant HIF PHD2, with IC50 values of 2,300,000 nM and 19,000 nM, respectively.
In assays involving human recombinant PHD2 expressed in Escherichia coli, Fumaric acid exhibits an IC50 of 19,090 nM and demonstrates inhibition of the enzyme with a half-life of 6 hours. It is also a selective inhibitor of carbonic anhydrase isoforms, specifically showing more potent inhibition towards carbonic anhydrase 2 (Kinact of 10.5 μM) than isoform 1 (Kinact of 395 μM).
Fumaric acid manifests other notable bioactivities, including agonism of the Thyroid Stimulating Hormone Receptor, and antagonism of the retinoid-related orphan receptor gamma. It induces DNA re-replication in SW480 colon adenocarcinoma cells and exhibits activity against HP1-beta Chromodomain interactions and ELG1-dependent DNA repair processes in HEK293T cells.
Moreover, it shows moderate liver toxicity, confirmed by elevated serum activity levels of ALT or AST in 59% of clinical trial cases, without causing any acute liver toxicity or other severe liver conditions. Additionally, it inhibits urease activity in bacterial strains and human FBPase, and shows interaction with bacterial and human enzymes including FBPase and recombinant PHDs, with varying degrees of efficacy.
Fumaric acid also demonstrates binding affinity towards several human receptors, exuding a manifold interaction profile across multiple biological pathways, indicating potential therapeutic applications contingent upon further detailed evaluations..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes. |
| Synonyms | Trans-Butenedioic acid, Lichenic acid, Fumarate, Donitic acid, Allomaleic acid, 2-Butenedioic acid |
| Molecular Weight | 116.07 |
| Formula | C4H4O4 |
| Cas No. | 110-17-8 |
| Smiles | C(=C/C(O)=O)\C(O)=O |
| Relative Density. | 1.64. Temperature:20 °C. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 62.5 mg/mL (538.47 mM), Sonication is recommended.  Chloroform, Dichloromethane, Ethyl Acetate, Acetone: Soluble | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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