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Fluvoxamine maleate

Catalog No. T1077 CAS 61718-82-9

Synonyms: MK-264, DU-23000 (maleate)

Fluvoxamine maleate (DU-23000 (maleate)) is a selective serotonin reuptake inhibitor that is used in the treatment of depression and a variety of anxiety disorders.

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Fluvoxamine maleate, CAS 61718-82-9

Pack Size	Availability	Price/USD
10 mg	In stock	$ 47.00
25 mg	In stock	$ 63.00
50 mg	In stock	$ 77.00
100 mg	In stock	$ 117.00
200 mg	In stock	$ 173.00
500 mg	In stock	$ 292.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.97%

Purity: 99.92%

Biological Description

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Storage & Solubility Information

Description	Fluvoxamine maleate (DU-23000 (maleate)) is a selective serotonin reuptake inhibitor that is used in the treatment of depression and a variety of anxiety disorders.
In vitro	Fluvoxamine increases [5-HT]ex levels in rat the prefrontal cortex and thalamus, and also increases [DA]ex levels in the striatum. [1] Fluvoxamine maleate ameliorates tactile allodynia via spinal 5-HT2A/2C receptors, by acting on the receptors or 5-HT neurons. [2]
In vivo	Fluvoxamine maleate also exhibits the antinociception in a dose-dependent manner in the paw pressure test in non-ligated mice. Fluvoxamine maleate also induces antinociceptive effect in the acute paw pressure test, and this effect is antagonized by the 5-HT3 receptor antagonist granisetron. [2] Fluvoxamine (10 and 30 mg/kg, i.p.) enhances synaptic efficacy in the hippocampo-mPFC pathway in a dose-dependent manner in the rat hippocampo-medial prefrontal cortex (mPFC). [3] Fluvoxamine (10 and 30 mg/kg, i.p.) suppresses long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP is completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by the 5-HT(4) receptor antagonist GR 113808 (20 mg/rat, i.c.v.) and the 5-HT(7) receptor antagonist DR 4004 (10 mg/rat, i.c.v.). [4] Fluvoxamine maleate reinforces the response to norepinephrine of isolated rat vas deferens incubated in Krebs-Henseleit solution. Fluvoxamine maleate and Fluoxetine hydrochloride inhibit the contraction induced by potassium ion on the isolated rat uterus preparation with IC50 of 3.99 μM and 18.2 μM, respectively. [5]

Synonyms	MK-264, DU-23000 (maleate)
Molecular Weight	434.41
Formula	C19H25F3N2O6
CAS No.	61718-82-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 200.3 mM

References and Literature

1. Denys D, et al. Psychopharmacology (Berl),2004, 176(2), 195-203. 2. Honda M, et al. Neuropharmacology,2006, 51(4), 866-872. 3. Ohashi S, et al. Brain Res,2002, 949(1-2), 131-138. 4. Kojima T, et al. Brain Res,2003, 959(1), 165-168. 5. Velasco A, et al. Gen Pharmacol,1997, 28(4), 509-512.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Cancer Drug Library Inhibitor Library Membrane Protein-targeted Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Approved Drug Library Anti-Obesity Compound Library Fluorochemical Library

Related Products

Related compounds with same targets

Olanzapine GSK163090 DA-6886 SB-269970 GR 113808 (R)-Mirtazapine D3 Tianeptine Eletriptan hydrobromide

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Keywords

Fluvoxamine maleate 61718-82-9 GPCR/G Protein Neuroscience 5-HT Receptor Serotonin Transporter inhibit SLC6A4 DU-23000 Fluvoxamine MK 264 DU23000 MK264 Fluvoxamine Maleate SERT 5-HTT MK-264 DU 23000 DU-23000 (maleate) Inhibitor inhibitor

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