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Etodolac

Catalog No. T1002 CAS 41340-25-4

Synonyms: Ultradol, AY-24236, Etodolic acid, Lodine

Etodolac (AY-24236) inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, and inflammation. Etodolac is a pyranocarboxylic acid and non-steroidal anti-inflammatory drug (NSAID) with antipyretic and analgesic activities. It also inhibits platelet aggregation by blocking platelet cyclooxygenase and the subsequent formation of thromboxane A2.

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Etodolac, CAS 41340-25-4

Pack Size	Availability	Price/USD
25 mg	In stock	$ 34.00
50 mg	In stock	$ 48.00
100 mg	In stock	$ 68.00
200 mg	In stock	$ 97.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.92%

Purity: 99.84%

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Storage & Solubility Information

Description	Etodolac (AY-24236) inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, and inflammation. Etodolac is a pyranocarboxylic acid and non-steroidal anti-inflammatory drug (NSAID) with antipyretic and analgesic activities. It also inhibits platelet aggregation by blocking platelet cyclooxygenase and the subsequent formation of thromboxane A2.
Targets&IC50	COX:53.5 nM
In vitro	Etodolac markedly inhibits ICl, vol activation by TNFα as well as subsequent apoptotic events such as apoptotic cell volume decrease (AVD) and elevation of caspase-3/7 activity in isolated rabbit articular chondrocytes. [1]
In vivo	Etodolac attenuates paclitaxel-induced peripheral neuropathy by a COX-independent pathway in a mouse model of mechanical allodynia. [2] Etodolac and other NSAIDs inhibits paw swelling and causes gastric mucosal lesions in adjuvant arthritic rats in a dose-dependent manner. Etodolac shows the highest UD(50) value and safety index among these NSAIDs in arthritic rats. Etodolac also shows the highest UD(50) value and safety index, except when its effects are assessed by acetic acid-induced writhing in normal rats. [3] Etodolac dose-dependently inhibits the development of gastric cancer, and no cancer is detected at a dose of 30 mg/kg/day. Etodolac does not affect the extent of inflammatory cell infiltration or oxidative DNA damage, but it significantly inhibits mucosal cell proliferation and dose-dependently represses the development of intestinal metaplasia in the stomachs of Helicobacter pylori (Hp)-infected Mongolian gerbils (MGs). [4] Etodolac alleviates heat-evoked hyperalgesia in the CCI rats and the increase in number of TRAP-positive multinucleated osteoclasts on the CCI-side is abrogated, however, it does not inhibit the decrease of bone mineral content (BMC) and bone mineral density (BMD) on the CCI-side. [5]

Synonyms	Ultradol, AY-24236, Etodolic acid, Lodine
Molecular Weight	287.35
Formula	C17H21NO3
CAS No.	41340-25-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 54 mg/mL (187.9 mM)

DMSO: 54 mg/mL (187.9 mM)

References and Literature

1. Kumagai K, et al. Int J Mol Sci,2013, 14(10), 19705-19715. 2. Ito S, et al. J Pharmacol Exp Ther,2012, 342(1), 53-60. 3. Tachibana M, et al. Pharmacology,2003, 68(2), 96-104. 4. Magari H, et al. Biochem Biophys Res Commun,2005, 334(2), 606-612. 5. Suyama H, et al. Brain Res,2004, 12010(1-2), 144-150.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Pancreatic Cancer Compound Library Drug-Fragment Library CNS-Penetrant Compound Library Bioactive Compound Library Bioactive Lipid Compound Library

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Keywords

Etodolac 41340-25-4 Immunology/Inflammation Metabolism Neuroscience Retinoid Receptor COX AY24236 Ultradol inhibit Inhibitor Cyclooxygenase AY 24236 AY-24236 Etodolic acid Lodine inhibitor

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