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Eflornithine hydrochloride hydrate

Catalog No. T2593 CAS 96020-91-6

Synonyms: Difluoromethylornithine hydrochloride hydrate, α-difluoromethylornithine hydrochloride hydrate, Eflornithine hydrochloride, MDL-71782 hydrochloride hydrate, DFMO hydrochloride hydrate, RMI-71782 hydrochloride hydrate, Eflornithine hydrochloride Monohydrate

Eflornithine hydrochloride hydrate (RMI-71782 hydrochloride hydrate) is a specific, irreversible inhibitor of ornithine decarboxylase.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Eflornithine hydrochloride hydrate Chemical Structure

Eflornithine hydrochloride hydrate, CAS 96020-91-6

Pack Size	Availability	Price/USD
50 mg	In stock	$ 30.00
100 mg	In stock	$ 42.00
200 mg	In stock	$ 58.00
500 mg	In stock	$ 124.00

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Purity: 99.64%

Purity: 99%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Eflornithine hydrochloride hydrate (RMI-71782 hydrochloride hydrate) is a specific, irreversible inhibitor of ornithine decarboxylase.
In vitro	When cultured cells are treated with α-difluoromethyl-Orn, an inhibitor of polyamine biosynthesis, production of hydrogen peroxide is suppressed and programmed cell death did not occur[1].
In vivo	Eflornithine stands as the only novel compound registered for human African trypanosomiasis treatment in the past five decades, primarily serving as an alternative for cases resistant to melarsoprol involving Trypanosoma brucei gambiense. Additionally, a 15% eflornithine cream demonstrates efficacy superior to placebo in diminishing excessive, unwanted facial hair growth in patients, with 58% of individuals treated with eflornithine observing at least some improvement in facial hirsutism after 24 weeks, compared to 34% of those receiving placebo. Furthermore, the inhibitory effect on hair growth by eflornithine cream is significantly amplified when applied to mouse skin previously treated with microneedles. In hypertensive rats with coarctation, eflornithine treatment normalizes contractile responses to KCI and norepinephrine, and enhances relaxations to acetylcholine within 14 days, indicating its broader pharmacological utility.
Cell Research	BY2 cells are treated with or without cryptogein in the presence or absence of DFMO(Difluoromethylornithine) and monitered the effect of chemicals on cell growth. (Only for Reference)

Synonyms	Difluoromethylornithine hydrochloride hydrate, α-difluoromethylornithine hydrochloride hydrate, Eflornithine hydrochloride, MDL-71782 hydrochloride hydrate, DFMO hydrochloride hydrate, RMI-71782 hydrochloride hydrate, Eflornithine hydrochloride Monohydrate
Molecular Weight	236.64
Formula	C6H15ClF2N2O3
CAS No.	96020-91-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (232.42 mM)

References and Literature

1. Yoda H, et al. Plant Physiol. 2006, 142(1):193-206. 2. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. 3. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. 4. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. 5. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312. 6. Dial C N. Modulation of Coxsackievirus Protease Activity by Polyamines[D]. Loyola University Chicago. 2019. 7. Dial C N, Tate P M, Kicmal T M, et al. Coxsackievirus B3 Responds to Polyamine Depletion via Enhancement of 2A and 3C Protease Activity[J]. Viruses. 2019 Apr 30;11(5). 8. Kicmal T M, Tate P M, Dial C N, et al. Polyamine depletion abrogates enterovirus cellular attachment[J]. Journal of virology. 2019, 93(20): e01054-19. 9. Mastrodomenico V, Esin J J, Graham M L, et al. Polyamine depletion inhibits bunyavirus infection via generation of noninfectious interfering virions[J]. Journal of virology. 2019 May 1. pii: JVI.00530-19.

Citations

1. Mastrodomenico V, Esin J J, Graham M L, et al. Polyamine depletion inhibits bunyavirus infection via generation of noninfectious interfering virions. Journal of Virology. 2019 May 1. pii: JVI.00530-19 2. Kicmal T M, Tate P M, Dial C N, et al. Polyamine depletion abrogates enterovirus cellular attachment. Journal of Virology. 2019, 93(20): e01054-19 3. Dial C N, Tate P M, Kicmal T M, et al. Coxsackievirus B3 Responds to Polyamine Depletion via Enhancement of 2A and 3C Protease Activity. Viruses. 2019 Apr 30;11(5) 4. Firpo M R, LoMascolo N J, Petit M J, et al.Polyamines and eIF5A hypusination facilitate SREBP2 synthesis and cholesterol production leading to enhanced enterovirus attachment and infection.PLoS pathogens.2023, 19(4): e1011317.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Inhibitor Library Highly Selective Inhibitor Library Drug Repurposing Compound Library Covalent Inhibitor Library Anti-COVID-19 Compound Library Bioactive Compound Library FDA-Approved Drug Library Bioactive Compounds Library Max Metabolism Compound Library

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Keywords

Eflornithine hydrochloride hydrate 96020-91-6 Metabolism Others Decarboxylase inhibit DFMO hydrochloride α-difluoromethylornithine hydrochloride α-difluoromethylornithine hydrochloride Hydrate Difluoromethylornithine hydrochloride hydrate α-difluoromethylornithine hydrochloride hydrate RMI-71782 hydrochloride Hydrate Eflornithine hydrochloride Hydrate Eflornithine hydrochloride MDL-71782 hydrochloride hydrate Eflornithine Hydrochloride MDL-71782 hydrochloride Hydrate Inhibitor a-difluoromethylornithine hydrochloride Hydrate Difluoromethylornithine hydrochloride Hydrate MDL-71782 hydrochloride DFMO hydrochloride hydrate RMI-71782 hydrochloride Parasite DFMO hydrochloride Hydrate RMI-71782 hydrochloride hydrate Eflornithine hydrochloride Monohydrate inhibitor

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