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Eflornithine hydrochloride hydrate

Catalog No. T2593   CAS 96020-91-6
Synonyms: DFMO hydrochloride hydrate, MDL-71782 hydrochloride hydrate, Eflornithine hydrochloride Monohydrate, Eflornithine hydrochloride, Difluoromethylornithine hydrochloride hydrate, RMI-71782 hydrochloride hydrate, α-difluoromethylornithine hydrochloride hydrate

Eflornithine hydrochloride is a specific, irreversible inhibitor of ornithine decarboxylase.

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Eflornithine hydrochloride hydrate, CAS 96020-91-6
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Purity 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Eflornithine hydrochloride is a specific, irreversible inhibitor of ornithine decarboxylase.
In vitro When cultured cells are treated with α-difluoromethyl-Orn, an inhibitor of polyamine biosynthesis, production of hydrogen peroxide is suppressed and programmed cell death did not occur[1].
In vivo Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[2]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[3]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[4]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[5].
Cell Research BY2 cells are treated with or without cryptogein in the presence or absence of DFMO(Difluoromethylornithine) and monitered the effect of chemicals on cell growth. (Only for Reference)
Synonyms DFMO hydrochloride hydrate, MDL-71782 hydrochloride hydrate, Eflornithine hydrochloride Monohydrate, Eflornithine hydrochloride, Difluoromethylornithine hydrochloride hydrate, RMI-71782 hydrochloride hydrate, α-difluoromethylornithine hydrochloride hydrate
Molecular Weight 236.64
Formula C6H15ClF2N2O3
CAS No. 96020-91-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 2.5 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

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References and Literature

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Anti-Cancer Metabolism Compound Library Inhibitor Library Anti-Metabolism Disease Compound Library Covalent Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library FDA-Approved Drug Library Anti-COVID-19 Compound Library Approved Drug Library

Related Products

Related compounds with same targets
4-Bromo-3-hydroxybenzoic acid Carbidopa Eflornithine hydrochloride hydrate Carbidopa monohydrate Tritoqualine L-Ornithine

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