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Econazole nitrate

Catalog No. T0444L CAS 24169-02-6

Synonyms: NSC 243115

Econazole nitrate (NSC-243115) (Spectazole) is an imidazole class antifungal medicine.

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Econazole nitrate, CAS 24169-02-6

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 30.00
1 mL * 10 mM (in DMSO)	In stock	$ 34.00

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Purity: 99.4%

Purity: 99%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Econazole nitrate (NSC-243115) (Spectazole) is an imidazole class antifungal medicine.

In vitro

Econazole nitrate is an effective inducer of micronuclei over a narrow dose range in cell lines V79, XEM2 and XEMd-MZ (expresses CYP1A2). [1] Econazole nitrate inhibits the proliferation of MCF-7 cells in a time- and dose-dependent manner by MTT method and colony forming assay. Econazole nitrate results in typical characteristics of apoptosis including the morphological changes and DNA fragmentation in MCF-7 cells. Econazole nitrate results in the decrease expression of procaspase-3, procaspase-9 and bcl-2. [2] Econazole inhibits ADP-ribose-activated currents in HEK-293 cells expressing recombinant human TRPM2 (hTRPM2). Econazole produces an essentially complete inhibition of the TRPM2-mediated current. [3] Econazole (25-50 mM) partially inhibits capacitative Ca2+ entry induced by cyclopiazonic acid, another endoplasmic reticulum Ca2+ pump inhibitor. Econazole induces Ca2+ influx via two separate pathways: one is sensitive to La3+, the other is not. [4] Econazole reversibly inhibits (Bu)(2)cAMP-stimulated progesterone production in a dose- and time-dependent manner in MA-10 cells without affecting total protein synthesis or P450(scc) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) enzyme expression or activity. [5] Econazole is a store-operated Ca2+ channel antagonist which induces cytotoxic cell death of leukemia. Econazole (5-20 mM) arrests human colon cancer cells at the G0/G1 phase of the cell cycle. Econazole induces COLO 205 cells apoptosis evidenced by ladder formation in DNA fragmentation assay and sub-G1 peak. [6]

Synonyms	NSC 243115
Molecular Weight	444.7
Formula	C18H15Cl3N2O·HNO3
CAS No.	24169-02-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 82 mg/mL (184.4 mM)

Ethanol: 5 mg/mL (11.24 mM)

References and Literature

1. Ferrer-Villada T, et al. Eur J Pharmacol,2006, 531(1-3), 1-8. 2. Sun J, et al. Iran J Pharm Res,2014, 13(4), 1327-1334. 3. Hill K, et al. Naunyn Schmiedebergs Arch Pharmacol,2004, 370(4), 227-237. 4. Jan CR, et al. Biochim Biophys Acta,1999, 1448(3), 533-542. 5. Walsh LP, et al. J Steroid Biochem Mol Biol,2000, 75(4-5), 229-236.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Antibiotics Library Pediatric Drug Library Approved Drug Library FDA-Approved Drug Library Anti-Infection Compound Library Anti-Bacterial Compound Library NO PAINS Compound Library Anti-Fungal Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Econazole nitrate 24169-02-6 Microbiology/Virology Antibacterial Antifungal Antibiotic Antifection NSC 243115 Fungal NSC-243115 NSC243115 Inhibitor inhibit Econazole Econazole Nitrate Bacterial inhibitor

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