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EGFR-IN-8

Catalog No. T11162   CAS 2407957-87-1

EGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC. EGFR-IN-8 is a dual EGFR and c-Met inhibitor.

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EGFR-IN-8 Chemical Structure
EGFR-IN-8, CAS 2407957-87-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 116.00
5 mg In stock $ 288.00
10 mg In stock $ 478.00
25 mg In stock $ 789.00
50 mg In stock $ 1,080.00
100 mg In stock $ 1,480.00
1 mL * 10 mM (in DMSO) In stock $ 422.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description EGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC. EGFR-IN-8 is a dual EGFR and c-Met inhibitor.
In vitro In A549, PC9, H1975, CL68, and CL97 cells, EGFR-IN-8 (0-0.6 μM; 48 hours) suppresses the expression of EGFR and c-Met in these five cell lines irrespective of their mutational status. EGFR-IN-8 (0-20 μM; 24, 48, 72 hours) exhibits a time- and dose-dependent inhibitory effect on the viability of A549, PC9, H1975, CL68, and CL97 cells at different time intervals, with IC50 values ranging from 0.3 to 0.6 μM and 0.2-0.5 μM after 48 and 72 h of treatment respectively[1].
In vivo EGFR-IN-8 (50,150 mg/kg; oral gavage) exhibits suppression (29% and 60%, respectively) of H1975 xenograft tumor growth in a dose-dependent manner[1].
Molecular Weight 662.02
Formula C32H23ClF3N7O4
CAS No. 2407957-87-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 8 mg/mL (12.08 mM), sonification is recommended.

TargetMolReferences and Literature

1. Dokla EME, et al. 1,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLC. Eur J Med Chem. 2019 Aug 9;182:111607.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Anti-Cancer Compound Library Anti-Prostate Cancer Compound Library Anti-Lung Cancer Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Bioactive Compound Library Anti-Liver Cancer Compound Library Anti-Colorectal Cancer Compound Library

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Keywords

EGFR-IN-8 2407957-87-1 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR c-Met/HGFR inhibit Epidermal growth factor receptor EGFR IN 8 ErbB-1 HER1 Inhibitor EGFRIN8 inhibitor

 

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