Shopping Cart

Your shopping cart is currently empty

Dyclonine hydrochloride

Name: Dyclonine hydrochloride
Brand: TargetMol
SKU: T1389
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T1389Cas No. 536-43-6

Alias Dyclonine HCl, Dyclocaine hydrochloride

Dyclonine hydrochloride (Dyclonine HCl) , an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .

Dyclonine hydrochloride

Copy Product Info

🥰Excellent

Purity: 99.35%

Catalog No. T1389Alias Dyclonine HCl, Dyclocaine hydrochlorideCas No. 536-43-6

Dyclonine hydrochloride (Dyclonine HCl) , an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$45	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.35%

Appearance:Solid

Color:White

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Dyclonine hydrochloride AI Summary

Dyclonine hydrochloride exhibits multiple bioactivities, including the inhibition of various interactions and cellular functions, such as modulators of lamin A splicing, thyroid hormone receptor inhibitors, SMN2 splice variant enhancers, and inhibitors of tau fibril formation, aldehyde dehydrogenase, Schistosoma mansoni peroxiredoxins, and influenza NS1 protein. It also inhibits ROR gamma transcriptional activity, cytochrome P450 3A4, chronic active B-cell receptor signaling, histone lysine methyltransferase G9a, vitamin D receptor interactions, HP1-beta chromodomain interactions, mammalian selenoprotein thioredoxin reductase 1, regulator of G protein signaling 4, TGF-b, cell surface uPA generation, Marburg Virus binding or entry into cells, HIV-1 protein Vpr, and is an activator of Nrf2. Additionally, it induces DNA re-replication and synthetic lethality in tumor cells producing 2HG, and blocks Ebola Virus entry. The compound demonstrates cytotoxicity against BESM cells with an EC50 of 36000.0 nM and shows antitrypanosomal activity against Trypanosoma cruzi amastigotes with an EC50 of 15000.0 nM. It has a selectivity window ratio of 2.4 for BESM cells and T. cruzi-infected cells. Additionally, Dyclonine hydrochloride effectively inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells, with inhibition rates of 83.62% and 170.92%, respectively, at 10 uM. In terms of antiviral activity, Dyclonine hydrochloride inhibits cell viability in Vero E6 cells infected with SARS-CoV-2, showing an inhibition index of 1.119 relative to the arbidol control. It also inhibits cytotoxicity in Caco-2 and Vero-6 cells exposed to SARS-CoV-2 at 10 µM with inhibition rates of -3.77% and -0.08%, respectively. However, it showed a negative inhibition percentage of -2.252% in the SARS-CoV-2 3CL-Pro protease inhibition assay at 20 µM concentration. Lastly, Dyclonine hydrochloride has cytotoxic effects on human HepG2 cells, with an IC50 of 9900.0 nM, indicating its potency in inhibiting the viability of these cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dyclonine hydrochloride (Dyclonine HCl) , an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .
Targets&IC50	ALDH3:76 μM, ALDH2:35 μM
Synonyms	Dyclonine HCl, Dyclocaine hydrochloride

Chemical Properties

Molecular Weight	325.87
Formula	C₁₈H₂₇NO₂·HCl
Cas No.	536-43-6
Smiles	c1(ccc(cc1)OCCCC)C(=O)CCN1CCCCC1.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 21.74 mg/mL (66.71 mM), Sonication is recommended.

Ethanol: 34 mg/mL (104.34 mM), Sonication is recommended.

DMSO: 16.67 mg/mL (51.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.0687 mL	15.3435 mL	30.6871 mL	153.4354 mL
5 mM	0.6137 mL	3.0687 mL	6.1374 mL	30.6871 mL
10 mM	0.3069 mL	1.5344 mL	3.0687 mL	15.3435 mL
20 mM	0.1534 mL	0.7672 mL	1.5344 mL	7.6718 mL
50 mM	0.0614 mL	0.3069 mL	0.6137 mL	3.0687 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc