Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DuP-697 is an irreversible and specific inhibitor of COX-2 with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 shows antiproliferative activity with an IC50 of 42.8 nM. DuP-697 exhibits antiangiogenic, anti-inflammatory, antipyretic and apoptotic effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 89.00 | |
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 323.00 | |
25 mg | In stock | $ 553.00 | |
50 mg | In stock | $ 789.00 | |
100 mg | In stock | $ 1,070.00 | |
500 mg | In stock | $ 2,150.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 239.00 |
Description | DuP-697 is an irreversible and specific inhibitor of COX-2 with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 shows antiproliferative activity with an IC50 of 42.8 nM. DuP-697 exhibits antiangiogenic, anti-inflammatory, antipyretic and apoptotic effects. |
Targets&IC50 | COX-2 (human):10 nM, COX-1 (human):800 nM |
In vitro | In HT29 cells, DuP-697 (25-100 nM) causes apoptosis in a concentration-dependent manner. DuP-697 in 1, 10, and 100 nM concentrations cause antiangiogenic effects in HT29 colorectal cancer cells with antiangiogenic scores of 0.5, 0.8, and 1.2[1]. |
In vivo | DuP-697 inhibits bull seminal vesicle prostaglandin synthesis with an IC50 value of 24 μM and rat brain PG synthesis with an IC50 value of 4.5 μM[2]. |
Molecular Weight | 411.31 |
Formula | C17H12BrFO2S2 |
CAS No. | 88149-94-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36.9 mg/mL(90.0 mM)
You can also refer to dose conversion for different animals. More
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DuP-697 88149-94-4 Immunology/Inflammation Neuroscience COX DuP697 DuP 697 inhibitor inhibit