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Daptomycin

Catalog No. T1665   CAS 103060-53-3
Synonyms: LY146032

Daptomycin (LY146032) is a cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.

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Daptomycin Chemical Structure
Daptomycin, CAS 103060-53-3
Pack Size Availability Price/USD Quantity
10 mg In stock $ 42.00
25 mg In stock $ 62.00
50 mg In stock $ 90.00
100 mg In stock $ 171.00
200 mg In stock $ 271.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 100%
Purity: 100%
Purity: 100%
Purity: 99.02%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Daptomycin (LY146032) is a cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.
In vivo Daptomycin at a dose of 10 mg/kg given twice daily, resulted in a reduction in the number of organisms per kidney significantly compared with that in infected untreated controls within 48 h after the initiation of therapy. At 20 mg/kg given once a day, daptomycin is less effective but reduces colony counts significantly after 4 days of therapy, and its activity is comparable to that of vancomycin or vancomycin-gentamicin given twice daily[4].
Synonyms LY146032
Molecular Weight 1620.67
Formula C72H101N17O26
CAS No. 103060-53-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 32.4 mg/mL (20 mM)

DMSO: 162.1 mg/mL (100 mM)

TargetMolReferences and Literature

1. Silverman JA, et al. Antimicrob Agents Chemother, 2003, 47(8), 2538-2544. 2. Rybak MJ, et al. Antimicrob Agents Chemother, 2000, 44(4), 1062-1066. 3. Steenbergen JN, et al. J Antimicrob Chemother, 2005, 55(3), 283-288. 4. Miniter PM, et al. Activity of LY146032 in vitro and in experimental enterococcal pyelonephritis. Antimicrob Agents Chemother. 1987 Aug;31(8):1199-203.

TargetMolCitations

1. Zhou Y, Liu M J, Liao X Y, et al.New Attempts to Inhibit Methicillin-Resistant Staphylococcus aureus Biofilm? A Combination of Daptomycin and Azithromycin.Infection and Drug Resistance.2023: 7029-7040.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Microbial Natural Product Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Inhibitor Library ReFRAME Related Library Anti-Bacterial Compound Library Cell Cycle Compound Library Antibiotics Library Immunology/Inflammation Compound Library

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Daptomycin 103060-53-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology DNA/RNA Synthesis Antibiotic Antibacterial LY 146032 LY146032 Bacterial LY-146032 inhibit Inhibitor inhibitor

 

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