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DETA NONOate

Catalog No. T36033   CAS 146724-94-9
Synonyms: NOC-18, Diethylamine NONOate

DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor with vasodilatory and antidepressant activity.DETA NONOate can be used to activate inward currents in neurons, which may accelerate the healing of MRSA-infected wounds.

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DETA NONOate Chemical Structure
DETA NONOate, CAS 146724-94-9
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Biological Description
Chemical Properties
Storage & Solubility Information
Description DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor with vasodilatory and antidepressant activity.DETA NONOate can be used to activate inward currents in neurons, which may accelerate the healing of MRSA-infected wounds.
In vitro By reducing the expression of glycopeptidolipids (GPL) in M. abscessus subspecies abscessus (Mab), DETA NONOate (100 μM; 16 h) induces the growth of nontuberculous mycobacteria (NTM) complex in the R morphotype[3].
In vivo DETA NONOate (15-150 μg/rat, intracerebroventricular injection, once) exhibits nociceptor-activating effects in the formalin model in rats[4].
At a concentration of 1 µM, DETA NONOate can reduce ischemia or ischemia/reperfusion-induced mitochondrial damage in the heart and prevent apoptotic cell death[2].
Synonyms NOC-18, Diethylamine NONOate
Molecular Weight 163.18
Formula C4H13N5O2
CAS No. 146724-94-9

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

aqueous buffers: >100 mg/mL

H2O: 30 mg/mL (183.85 mM), when pH is adjusted to 9 with NaOH. Sonication is recommended.

DMSO: <1 mg/mL (Insoluble)

TargetMolReferences and Literature

1. Soichiro Sonoda, et al. Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells. Sci Rep. 2018 Feb 21;8(1):3419. 2. Umbrasas D, et al. Nitric Oxide Donor NOC-18-Induced Changes of Mitochondrial Phosphoproteome in Rat Cardiac Ischemia Model. Medicina (Kaunas). 2019 Sep 24;55(10):631. 3. Nandanwar N, et al. Growth medium and nitric oxide alter Mycobacterium abscessus morphotype and virulence. Microbiol Res. 2021 Dec;253:126887. 4. S Shibuta, et al. A new nitric oxide donor, NOC-18, exhibits a nociceptive effect in the rat formalin model. EJ Neurol Sci. 1996 Sep 15;141(1-2):1-5

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Keywords

DETA NONOate 146724-94-9 Immunology/Inflammation NO Synthase NOC-18 Diethylamine NONOate inhibitor inhibit

 

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