Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 115.00 | |
5 mg | In stock | $ 280.00 | |
10 mg | In stock | $ 415.00 | |
25 mg | In stock | $ 689.00 | |
50 mg | In stock | $ 983.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 290.00 |
Description | Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration. |
In vitro | The effect of CMG neutral extract (25-200 microg/ml) and Tirucallol (0.1-100 microM) on the following: 1) the expression of adhesion molecules (VCAM-1 and ICAM-1) by Cell ELISA and 2) the attachment of monocytes (U937 cells) in TNF-alpha stimulated Human Aortic Endothelial Cells (HAEC) by Adhesion assay. The impact of treatment with CMG neutral extract and Tirucallol in NFkB phosphorylation was also examined by a cell-based ELISA kit. Both CMG extract and Tirucallol inhibit significantly VCAM-1 and ICAM-1 expression in TNF-alpha-stimulated HAEC. They also inhibit significantly the binding of U937 cells to TNF-alpha-stimulated HAEC and attenuate the phosphorylation of NFkB p65. |
Source |
Molecular Weight | 426.72 |
Formula | C30H50O |
CAS No. | 514-46-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.27 mg/mL (10 mM), Sonification is recommended
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tirucallol 514-46-5 GPCR/G Protein Immunology/Inflammation NOS NO Synthase Prostaglandin Receptor antiinflammatory triterpene Euphorbia tetracyclic inhibit Inhibitor lacteal latex inhibitor