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DA-6886

Catalog No. T27117 CAS 1645260-76-9

Synonyms: DA6886, DA 6886

DA-6886 is an agonist 5-Hydroxytryptamine receptor 4 (5-HT4). DA-6886 induced relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels revealed that it inhibited hERG channel current with an pIC50 value of 4.3, indicating that the compound was 1000-fold more selective for the 5-HT4 receptor over hERG channels.

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DA-6886, CAS 1645260-76-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 140.00
5 mg	In stock	$ 340.00
10 mg	In stock	$ 510.00
25 mg	In stock	$ 828.00
50 mg	In stock	$ 1,150.00
100 mg	In stock	$ 1,550.00
500 mg	In stock	$ 2,970.00

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Purity: 99.89%

Purity: 98.78%

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Description

In vivo

In the normal ICR mice, DA-6886 (0.4 and 2mg/kg; oral) resulted in a marked stimulation of colonic transit. In the loperamide-induced constipation mouse model, DA-6886 (2mg/kg) significantly improved the delay of colonic transit. Taken together, DA-6886 is a highly potent and selective 5-HT4 receptor agonist to accelerate colonic transit in mice, which might be a therapeutic agent having a favorable safety profile in the treatment of gastrointestinal motor disorders such as IBS-C and chronic constipation.[1]

Synonyms	DA6886, DA 6886
Molecular Weight	443.37
Formula	C19H28Cl2N6O2
CAS No.	1645260-76-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lee MJ, et al. Pharmacological profile of DA-6886, a novel 5-HT4 receptor agonist to accelerate colonic motor activity in mice. Eur J Pharmacol. 2014;735:115-122. 2. Lee DY, et al. Pharmacokinetics of DA-6886, A New 5-HT4 Receptor Agonist, in Rats. Pharmaceutics. 2022;14(4):70

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Membrane Protein-targeted Compound Library Neuronal Signaling Compound Library Neurotransmitter Receptor Compound Library Clinical Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

DA-6886 1645260-76-9 GPCR/G Protein Neuroscience 5-HT Receptor DA6886 DA 6886 inhibitor inhibit

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