Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cyclo(L-Phe-trans-4-hydroxy-L-Pro) (Cyclo(L-phenylalanyl-trans-4-hydroxy-L-proline)) is a natural product found in Phellinus igniarius.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 216.00 | |
2 mg | In stock | $ 323.00 | |
5 mg | In stock | $ 498.00 | |
10 mg | In stock | $ 725.00 | |
25 mg | In stock | $ 1,130.00 | |
50 mg | In stock | $ 1,520.00 | |
100 mg | In stock | $ 1,980.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 451.00 |
Description | Cyclo(L-Phe-trans-4-hydroxy-L-Pro) (Cyclo(L-phenylalanyl-trans-4-hydroxy-L-proline)) is a natural product found in Phellinus igniarius. |
In vitro | We previously identified Streptomyces griseus as an anti-cancer agent (Kim et al., 2014). In this study, we isolated compounds from S. griseus and evaluated their anticancer effect and toxicity in vitro and in vivo. METHODS AND RESULTS: Preparative centrifugal partition chromatography (CPC) was used to obtain three compounds, cyclo(L-[4-hydroxyprolinyl]- L -leucine], Cyclo(L-Phe-trans-4-hydroxy-L-Pro) and phenethyl acetate (PA). We chose PA, which had the highest anticancer activity, as a target compound for further experiments. PA induced the formation of apoptotic bodies, DNA fragmentation, DNA accumulation in G0/G1 phase, and reactive oxygen species (ROS) formation. Furthermore, PA treatment increased Bax/Bcl-xL expression, activated caspase-3, and cleaved poly-ADP-ribose polymerase (PARP) in HL-60 cells. Simultaneous evaluation in vitro and in vivo, revealed that PA exhibited no toxicity in Vero cells and zebrafish embryos. CONCLUSIONS: We revealed, for the first time, that PA generates ROS, and that this ROS accumulation induced the Bcl signaling pathway[1]. |
Synonyms | L-Phe-trans-4-hydroxy-L-Pro, Cyclo(L-phenylalanyl-trans-4-hydroxy-L-proline) |
Molecular Weight | 260.29 |
Formula | C14H16N2O3 |
CAS No. | 118477-06-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (192.09 mM)
You can also refer to dose conversion for different animals. More
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Cyclo(L-Phe-trans-4-hydroxy-L-Pro) 118477-06-8 Others L-Phe-trans-4-hydroxy-L-Pro Cyclo(L-phenylalanyl-trans-4-hydroxy-L-proline) inhibitor inhibit