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Cuminaldehyde

Cuminaldehyde
Cuminaldehyde (Cuminal) is a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity,with a pleasant smell and contributes to the aroma of essential oils.
Catalog No. T7441Cas No. 122-03-2
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Purity:98%
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Cuminaldehyde

Catalog No. T7441Cas No. 122-03-2
Cuminaldehyde (Cuminal) is a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity,with a pleasant smell and contributes to the aroma of essential oils.
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Pack SizePriceAvailabilityQuantity
5 g$43In Stock
10 g$62In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Product Introduction

Bioactivity
Description
Cuminaldehyde (Cuminal) is a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity,with a pleasant smell and contributes to the aroma of essential oils.
In vitro
Cuminaldehyde?suppressed growth and induced apoptosis, as proved by depletion of the mitochondrial membrane potential, activation of both caspase-3 and -9, and morphological features of apoptosis[1].
In vivo
In vivo, cuminaldehyde diminished the tumor burden ,cuminaldehyde could be a drug for chemopreventive or anticancer therapy[1]
Cell Research
Incubated the cells in the culture plate with 96 wells at the concentration of ten thousand cells per well.?After being incubated for 24 h, we treated the cells with cuminaldehyde at the concentration of 10, 20, 40, 80, or 160 μM for 12, 24, or 48 h. Determined cell viability using the Cell Proliferation Kit II (XTT) according to the supplier's instructions.?The value of absorbance was evaluated by a spectrophotometer (Tecan infinite M200, Tecan, M?nnedorf, Switzerland) using 492 nm wavelength with a reference of 650 nm wavelength[1].
Animal Research
Human colorectal COLO 205 cells (5 × 10^6 cells in 200 μL of culture medium) were subcutaneously injected into the mice's flanks.?Treatment was started when the tumors reached about 75 mm^3.?Thirty-two mice were divided randomly into four groups (eight mice/group).?Cuminaldehyde-treated mice received intratumoral injection of 5, 10, or 20 mg/kg/day of cuminaldehyde in a 200 μL volume (the solutions were prepared from stock solution of cuminaldehyde in dimethyl sulfoxide and diluted into appropriate concentrations in PBS) daily.?The mice in the control group were treated with an equal volume of vehicle.?After transplantation, body weight as well as tumor size were monitored at weekly intervals.?Tumor size was measured using calipers, and tumor volume was calculated using the hemiellipsoid model formula[1]
AliasCuminic aldehyde, Cuminal
Chemical Properties
Molecular Weight148.2
FormulaC10H12O
Cas No.122-03-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (168.69 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.7476 mL33.7382 mL67.4764 mL337.3819 mL
5 mM1.3495 mL6.7476 mL13.4953 mL67.4764 mL
10 mM0.6748 mL3.3738 mL6.7476 mL33.7382 mL
20 mM0.3374 mL1.6869 mL3.3738 mL16.8691 mL
50 mM0.1350 mL0.6748 mL1.3495 mL6.7476 mL
100 mM0.0675 mL0.3374 mL0.6748 mL3.3738 mL

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