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Cinnamic acid

Catalog No. T5646 CAS 621-82-9

Synonyms: 3-Phenylacrylic acid, β-Phenylacrylic acid

Cinnamic acid (β-Phenylacrylic acid) has potential use in cancer intervention,The concentration causing a 50% reduction of cell proliferation (IC50) ranged from 1 to 4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.

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Cinnamic acid, CAS 621-82-9

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100 mg	In stock	$ 41.00

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Purity: 98%

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Description	Cinnamic acid (β-Phenylacrylic acid) has potential use in cancer intervention,The concentration causing a 50% reduction of cell proliferation (IC50) ranged from 1 to 4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.
In vivo	Oinnamic acid?exerts anti-diabetic activity by improving glucose tolerance in vivo and stimulating insulin secretion in vitro.
Animal Research	Non-obese type 2 diabetes was developed by injecting 90 mg/kg streptozotocin in 2-day-old Wistar pups. Cinnamic acid and cinnamaldehyde were administered orally to diabetic rats for assessing acute blood glucose lowering effect and improvement of glucose tolerance. Additionally, insulin secretory activity of cinnamic acid and cinnamaldehyde was evaluated in isolated mice islets. Cinnamic acid, but not cinnamaldehyde, decreased blood glucose levels in diabetic rats in a time- and dose-dependent manner. Oral administration of cinnamic acid with 5 and 10 mg/kg doses to diabetic rats improved glucose tolerance in a dose-dependent manner. The improvement by 10 mg/kg cinnamic acid was comparable to that of standard drug glibenclamide (5 mg/kg).
Source	Natural Products > Lauraceae > Cinnamomum

Synonyms	3-Phenylacrylic acid, β-Phenylacrylic acid
Molecular Weight	148.16
Formula	C9H8O2
CAS No.	621-82-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 50 mg/mL (337.47 mM)

References and Literature

1. Hafizur R M , Hameed A , Shukrana M , et al. Cinnamic acid exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro[J]. Phytomedicine, 2015, 22(2):297-300.

Related compound libraries

This product is contained In the following compound libraries：

Tobacco Monomer Library Anti-Cancer Active Compound Library Miao medicine Compound Library Gut Microbial Metabolite Library Bioactive Compounds Library Max Anti-Tumor Natural Product Library Food as Medicine Compound Library Covalent Inhibitor Library NO PAINS Compound Library Natural Product Library for HTS

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Keywords

Cinnamic acid 621-82-9 Metabolism Endogenous Metabolite inhibit b-Phenylacrylic acid 3-Phenylacrylic acid beta-Phenylacrylic acid β-Phenylacrylic acid Inhibitor inhibitor

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