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Cefdinir

Catalog No. T0133 CAS 91832-40-5

Synonyms: FK-482, CI-983, PD 134393

Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat and skin.

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Cefdinir, CAS 91832-40-5

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 54.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.94%

Purity: 99.89%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat and skin.
In vitro	Cefdinir, a new oral 2-amino-5-thiazolyl cephalosporin, inhibits the luminol-amplified chemiluminescence (LACL) response of human neutrophils stimulated by PMA but not opsonized zymosan, in a concentration-dependent but not time-dependent manner. Cefdinir inhibits LACL generation in cell-free systems consisting of Water2, NaI, and either horseradish peroxidase or amyeloperoxidase-containing neutrophil extract. Cefdinir impairs LACL response induced by the calcium ionophore A23187 and FMLP, and this impairment is increased in cytochalasin B-treated neutrophils. Cefdinir directly inhibits the activity of myeloperoxidase-containing neutrophil extract released into the extracellular medium during neutrophil stimulation by soluble mediators, but has no effect on that released into the phagolysosome during phagocytosis. [1] Cefdinir demonstrates excellent activity against a wide range of gram-positive and gram-negative bacteria. Cefdinir is resistant to a broad variety of β-lactamases and exhibits a β-lactam stability profile generally better than those observed with cefaclor and cefuroxime. Cefdinir elimination is primarily mediated by the kidney. Cefdinir interacts with the dipeptide transporters PEPT1 and PEPT2. Cefdinir tubular reabsorption is substantial, that Cefdinir tubular secretion is inhibitable by probenecid, and that this secretion is probably mediated by the renal organic anion secretory pathway. [2]
Kinase Assay	Topoisomerase II activity assay: Nuclear extracts are prepared, and nuclei are isolated. The activity of topoisomerase II is calculated from the percentage of decatenation obtained. Tritiated kinoplast DNA (KDNA 0.22 μg) is used as a substrate. Etoposide and topoisomerase II are incubated for 30 min at 37 ℃ and are stopped with 1% sodium dodecyl sulfate (SDS) and proteinase K (100 μg/mL). The percentages of decatenation and inhibition of topoisomerase II by Etoposide are obtained.

Synonyms	FK-482, CI-983, PD 134393
Molecular Weight	395.41
Formula	C14H13N5O5S2
CAS No.	91832-40-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 73 mg/mL (184.6 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Labro MT, et al. J Immunol,1994, 152(5), 2447-2455. 2. Lepsy CS, et al. Antimicrob Agents Chemother,2003, 47(2), 689-696.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Immunology/Inflammation Compound Library Anti-Infection Compound Library FDA-Approved Drug Library Anti-COVID-19 Compound Library ReFRAME Related Library Beta-Lactam Compound Library Human Metabolite Library Metabolism Compound Library Clinical Compound Library

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Keywords

Cefdinir 91832-40-5 Metabolism Microbiology/Virology Glutathione Peroxidase Antibiotic Antibacterial FK-482 cephalosporin CI 983 PD-134393 Inhibitor Bacterial Gram-positive Gram-negative PD134393 inhibit CI983 FK 482 bacteria CI-983 FK482 PD 134393 inhibitor

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