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Carbaryl

Name: Carbaryl
Brand: TargetMol
SKU: T0790
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0790Cas No. 63-25-2

Alias Sevin, 1-naphthyl methylcarbamate

Carbaryl (1-naphthyl methylcarbamate) is a carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries.

Carbaryl

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Purity: 99.75%

Catalog No. T0790Alias Sevin, 1-naphthyl methylcarbamateCas No. 63-25-2

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$29	In Stock	In Stock
100 mg	$40	In Stock	In Stock
500 mg	$92	In Stock	In Stock
1 g	$133	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.75%

Color:White

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COA HNMR LCMS

Product Introduction

Carbaryl AI Summary

Carbaryl exhibits diverse bioactivities across several biochemical pathways and cellular processes. It is a potent inhibitor of multiple forms of acetylcholinesterase (AChE) from various sources including bovine erythrocytes, eel, and insects, with IC50 values ranging from 29.0 nM to 57400.0 nM. The compound also shows insecticidal activity against several pests such as southern Corn rootworm, Anopheles gambiae mosquitoes, Nephotettix cincticeps, Musca domestica, Dendroctonus ponderosae, and Drosophila suzukii, with LD50 values highlighting its potent efficacy. Its highest insecticidal activity is noted in assays with potent low LC50 values. Additionally, Carbaryl exhibits bioactivity as an inhibitor of fatty acid amide hydrolase (FAAH) in rat brain membranes and human FAAH with IC50 values greater than 30000.0 nM. It shows notable inhibition of SARS-CoV-2 3CL-Pro protease and displays antiviral activity against SARS-CoV-2-induced cytotoxicity in Caco-2 and VERO-6 cells at varied concentrations. Carbaryl also disrupts mitochondrial membrane potential, has selectivity towards AChE in Anopheles gambiae compared to human AChE, and shows an array of effects on signaling pathways, including GCN5L2, ERK, p53, and several others. Furthermore, it demonstrates high genotoxic activity in soybean, contact toxicity towards Trichogramma nubilale, and significant effects on Daphnia magna and Cheumatopsyche brevilineata larvae. Overall, Carbaryl is a multifunctional compound with significant biochemical and physiological effects, notably as an insecticide and antiviral agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Carbaryl (1-naphthyl methylcarbamate) is a carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries.
Synonyms	Sevin, 1-naphthyl methylcarbamate

Chemical Properties

Molecular Weight	201.22
Formula	C₁₂H₁₁NO₂
Cas No.	63-25-2
Smiles	CNC(=O)OC1=CC=CC2=CC=CC=C12
Relative Density.	1.183 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (248.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9697 mL	24.8484 mL	49.6968 mL	248.4842 mL
5 mM	0.9939 mL	4.9697 mL	9.9394 mL	49.6968 mL
10 mM	0.4970 mL	2.4848 mL	4.9697 mL	24.8484 mL
20 mM	0.2485 mL	1.2424 mL	2.4848 mL	12.4242 mL
50 mM	0.0994 mL	0.4970 mL	0.9939 mL	4.9697 mL
100 mM	0.0497 mL	0.2485 mL	0.4970 mL	2.4848 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc