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CK-869

Catalog No. T5860 CAS 388592-44-7

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor(IC50 of 7 μM),and is useful tools for the investigation of the Arp2/3 complex.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CK-869, CAS 388592-44-7

Pack Size	Availability	Price/USD
2 mg	In stock	$ 34.00
5 mg	In stock	$ 55.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 178.00
50 mg	In stock	$ 289.00
100 mg	In stock	$ 463.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 98%

Biological Description

Chemical Properties

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Description	CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor(IC50 of 7 μM),and is useful tools for the investigation of the Arp2/3 complex.
Targets&IC50	ARP2:7 μM, ARP3:7 μM
In vitro	CK-869 inhibits comet tail formation by L. monocytogenes with an IC50 value of 7 μM.It also impairs cell adhesion and cell spreading in MCF10A human breast epithelial cells[1].
Cell Research	Cells were treated in suspension with different concentrations of the compounds, allowed to adhere to the surface of a tissue culture dish for one hour, washed and the number of adherent cells counted and presented as a fraction of untreated cells (10X lens, 10 fields/condition).?For cell spreading assays, cells were treated with CK-869 in suspension, plated on coverslips coated with 5 μg/ml fibronectin for imaging[1].

Molecular Weight	394.28
Formula	C17H16BrNO3S
CAS No.	388592-44-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 75 mg/mL (190.22 mM)

References and Literature

1. Yvonne B , Vasquez R J , Jonathan S , et al. Arp2/3 Inhibition Induces Amoeboid-Like Protrusions in MCF10A Epithelial Cells by Reduced Cytoskeletal-Membrane Coupling and Focal Adhesion Assembly[J]. PLoS ONE, 2014, 9(6):e100943-. 2. Yamagishi Y , Oya K , Matsuura A , et al. Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo[J]. Biochemical and Biophysical Research Communications, 2018, 496(3):834-839. 3. Hetrick B , Han M , Helgeson L , et al. Small Molecules CK-666 and CK-869 Inhibit Actin-Related Protein 2/3 Complex by Blocking an Activating Conformational Change[J]. Chemistry & Biology, 2013, 20(5):701-712.

Related compound libraries

This product is contained In the following compound libraries：

Microtubule-Targeted Compound Library Inhibitor Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compounds Library Max Anti-Aging Compound Library Bioactive Compound Library NO PAINS Compound Library Anti-Cardiovascular Disease Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CK-869 388592-44-7 Cytoskeletal Signaling Microtubule Associated Arp2/3 Complex inhibit Inhibitor CK869 Actin-related protein 2/3 complex CK 869 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.