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CCB02

Name: CCB02
Brand: TargetMol
SKU: T10704
Price: 70 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10704Cas No. 2100864-57-9

CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity, showing no inhibition on cell cycle- and centrosome-related kinases, nor affecting the phosphorylation status of Aurora-A, CDK2, Plk1, Plk2, and CHK1.

CCB02

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Purity: 98.38%

Catalog No. T10704Cas No. 2100864-57-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$70	-	In Stock
5 mg	$173	-	In Stock
10 mg	$273	-	In Stock
25 mg	$533	-	In Stock
50 mg	$816	-	In Stock
100 mg	$1,110	-	In Stock
1 mL x 10 mM (in DMSO)	$191	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.38%

Appearance:Solid

Color:Yellow

Resource Download

COA CNMR HNMR LCMS

Product Introduction

Bioactivity

Description	CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity, showing no inhibition on cell cycle- and centrosome-related kinases, nor affecting the phosphorylation status of Aurora-A, CDK2, Plk1, Plk2, and CHK1.
Targets&IC50	CPAP-tubulin:689 nM
In vitro	CCB02 perturbs CPAP PN2-3-tubulin interaction with an IC50 of 0.441 μM in a PN2-3 CPAP-GST pull-down assay. In concentrations ranging from 0.1 to 15 μM over 72 hours, CCB02 inhibits the proliferation of cancer cells with extra centrosomes (IC50s: 0.86-2.9 μM). Additionally, CCB02 activates the spindle assembly checkpoint, induces PCM proteins recruitment to centrosomes, and enhances the microtubule nucleation activities of centrosomes[1].
In vivo	CCB02 (30 mg/kg, p.o. daily for 24 days) exhibits a potent anti-tumor effect in nude mice with subcutaneous human lung (H1975 T790M cells) tumor xenografts, suppresses MDA-MB-231 cell migration, and induces multipolar mitosis in mouse xenografts[1].

Chemical Properties

Molecular Weight	235.24
Formula	C₁₄H₉N₃O
Cas No.	2100864-57-9
Smiles	COc1ncc2cc3ccccc3nc2c1C#N
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (95.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (8.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2510 mL	21.2549 mL	42.5098 mL	212.5489 mL
5 mM	0.8502 mL	4.2510 mL	8.5020 mL	42.5098 mL
10 mM	0.4251 mL	2.1255 mL	4.2510 mL	21.2549 mL
20 mM	0.2125 mL	1.0627 mL	2.1255 mL	10.6274 mL
50 mM	0.0850 mL	0.4251 mL	0.8502 mL	4.2510 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc