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Butylphthalide

Catalog No. T4S0647 CAS 6066-49-5

Synonyms: 3-Butylphthalide, 3-n-Butylphathlide, 3-n-Butylphthalide

Butylphthalide (3-Butylphthalide) is an anti-cerebral-ischemia drug; first isolated from the seeds of Apium graveolens Linn.

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Butylphthalide, CAS 6066-49-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 48.00
10 mg	In stock	$ 76.00
25 mg	In stock	$ 123.00
50 mg	In stock	$ 177.00
100 mg	In stock	$ 263.00
1 mL * 10 mM (in DMSO)	In stock	$ 80.00

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Purity: 95.63%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Butylphthalide (3-Butylphthalide) is an anti-cerebral-ischemia drug; first isolated from the seeds of Apium graveolens Linn.
In vivo	Butylphthalide alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits [1]. Intragastric NBP administration to 4-month-old SAMP8 mice for 2 months significantly improved spatial learning and memory ability. Moreover, the loss of choline acetyltransferase (ChAT)-positive neurons in the medial septal nucleus and the vertical limb of the diagonal band in SAMP8 mice was slowed down, as was the decline in the protein and mRNA expression of ChAT in the hippocampus, cerebral cortex, and forebrain [2].
Source	Natural Products > Apiaceae > Ligusticum

Synonyms	3-Butylphthalide, 3-n-Butylphathlide, 3-n-Butylphthalide
Molecular Weight	190.24
Formula	C12H14O2
CAS No.	6066-49-5

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (236.54 mM)

References and Literature

1. Zhao W, et al. 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia. Neural Regen Res. 2014 Apr 1;9(7):719-26. 2. Wang F, et al. Improvement of cognitive deficits in SAMP8 mice by 3-n-butylphthalide. Neurol Res. 2014 Mar;36(3):224-33.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Drug Repurposing Compound Library Selected Plant-Sourced Compound Library Food Additive Library Natural Product Library Clinical Compound Library Bioactive Compounds Library Max NO PAINS Compound Library FDA-Approved & Pharmacopeia Drug Library Traditional Mongolian Medicine Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Butylphthalide 6066-49-5 Others inhibit 3-Butylphthalide 3-n-Butylphathlide 3-n-Butylphthalide Inhibitor inhibitor

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