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Catalog No. T2267   CAS 1637739-82-2

BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
BQU57, CAS 1637739-82-2
Pack Size Availability Price/USD Quantity
2 mg In stock $ 38.00
5 mg In stock $ 56.00
10 mg In stock $ 93.00
25 mg In stock $ 165.00
50 mg In stock $ 198.00
100 mg In stock $ 369.00
1 mL * 10 mM (in DMSO) In stock $ 62.00
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Purity: 98.72%
Purity: 98.59%
Purity: 98.36%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.
Kinase Assay HDAC Enzyme Assay: The commercially availablae human recombinant enzyme and fluorogenic HDAC assay kits have used to measure percent inhibition and IC50 values of three HDAC isozymes (HDAC2, HDAC4, HDAC6). Briefly, the inhibitor is added sequentially to a black, flat-bottom 96-well microtiter plate, and the reaction mixture is incubated for 30 min at 37°C. The potent HDAC inhibitor trichostatin A (included in the assay kit) is added to the bifunctional HDAC assay developer at a final reaction concentration of 1 μM to stop deacetylation and initiate the release of the fluorophore. The reaction mixture is further incubated at room temperature for 15 min. Fluorescence is measured on a Spectra Max Gemini XPS using an excitation wavelength of 360 nm and a detection wavelength of 460 nm.
Cell Research Growth inhibition on human lung cancer cells by the compounds are measured under anchorage-independent conditions in soft agar. Cells are seeded into 6-well plates (coated with a base layer made of 2.0 mL of 1% low-melting-point agarose) at 15,000 cells per well in 3.0 mL of 0.4% low-melting-point agarose containing various concentration of drug. Two to four weeks (depending on cell line) after incubation, cells are stained with 1.0 mg/mL Nitro Blue Tetrazolium and colonies are counted under a microscope. The IC50 values are defined as the concentration of drug that resulted in 50% reduction in colony number compared to DMSO treated control. After 48 hr, cells are subjected to the soft agar colony formation assay. (Only for Reference)
Molecular Weight 334.3
Formula C16H13F3N4O
CAS No. 1637739-82-2


Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

Ethanol: 16 mg/mL (47.9 mM)

DMSO: 61 mg/mL (182.5 mM)

H2O: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Yan C, et al. Nature. 2014, 515(7527), 443-447.

Related compound libraries

This product is contained In the following compound libraries:
Kinase Inhibitor Library Anti-Prostate Cancer Compound Library Anti-Cancer Compound Library Glutamine Metabolism Compound Library Inhibitor Library Fluorochemical Library Reprogramming Compound Library Bioactive Compounds Library Max Autophagy Compound Library Ferroptosis Compound Library

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BQU57 1637739-82-2 GPCR/G Protein MAPK GTPase Ras inhibit BQU-57 Inhibitor BQU 57 inhibitor