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BMS-1001

Catalog No. T8470 CAS 2113650-03-4

BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction(IC50 : 2.25 nM, in a homogenous time-resolved fluorescence binding assay).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

BMS-1001, CAS 2113650-03-4

Pack Size	Availability	Price/USD
5 mg	In stock	223.00
25 mg	In stock	666.00
50 mg	In stock	Inquiry
100 mg	In stock	Inquiry
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Purity 98.89%

HNMR HPLC COA

Datasheet SDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction(IC50 : 2.25 nM, in a homogenous time-resolved fluorescence binding assay).
Targets&IC50	PD-1/PD-L1

Molecular Weight	594.7
Formula	C35H34N2O7
CAS No.	2113650-03-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Skalniak L , Zak K M , Guzik K , et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells[J]. Oncotarget, 2017, 8(42).

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Inhibitor Library Anti-Cancer Compound Library Apoptosis Compound Library Immunology/Inflammation Compound Library Cell Cycle Compound Library Target-Focused Phenotypic Screening Library Immuno-Oncology Compound Library Anti-Breast Cancer Compound Library

Related Products

Related compounds with same targets

Pembrolizumab Nivolumab Avelumab Atezolizumab PDL-1 cpd 10 BMS-1001 Phellodendrine chloride BMS-1166

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.