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BJE6-106

Catalog No. T10555   CAS 1564249-38-2
Synonyms: B106

BJE6-106 (B106) is a potent, selective PKCδ inhibitor (IC50: 0.05 μM) and targets selectivity over classical PKCα (IC50: 50 μM). BJE6-106 induces caspase-dependent apoptosis with tumor-specific effect.

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BJE6-106 Chemical Structure
BJE6-106, CAS 1564249-38-2
Pack Size Availability Price/USD Quantity
25 mg 6-8 weeks $ 1,140.00
50 mg 6-8 weeks $ 1,490.00
100 mg 6-8 weeks $ 2,320.00
1 mL * 10 mM (in DMSO) 6-8 weeks $ 365.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description BJE6-106 (B106) is a potent, selective PKCδ inhibitor (IC50: 0.05 μM) and targets selectivity over classical PKCα (IC50: 50 μM). BJE6-106 induces caspase-dependent apoptosis with tumor-specific effect.
Targets&IC50 PKCα:50 μM, PKCδ:0.05 μM
In vitro BJE6-106 (0.2 μM, 0.5 μM; 6-24 hours) triggers caspase-dependent apoptosis, increases the activity of caspase 3/7, the effect of B106 is greater than rottlerin (10-fold) in SBcl2 cells. BJE6-106 (0.2 μM, 0.5 μM; 24-72 hours) suppresses cell survival in melanoma cell lines with NRAS mutations. BJE6-106 (0.5 μM; 2-10 hours) activates the MKK4-JNK-H2AX Pathway by inducing JNK, MKK4, and H2AX activation at different times in SBcl2 cells.
Synonyms B106
Molecular Weight 381.47
Formula C26H23NO2
CAS No. 1564249-38-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Takashima A,et al. Protein kinase Cδ is a therapeutic target in malignant melanoma with NRAS mutation. ACS Chem Biol. 2014 Apr 18;9(4):1003-14.

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Keywords

BJE6-106 1564249-38-2 Chromatin/Epigenetic Cytoskeletal Signaling PKC BJE6106 BJE-6-106 BJE6 106 B 106 B106 B-106 inhibitor inhibit

 

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