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Aminooxyacetic acid hemihydrochloride

Catalog No. T5880   CAS 2921-14-4
Synonyms: Carboxymethoxylamine Hemihydrochloride

Aminooxyacetic acid hemihydrochloride (Carboxymethoxylamine Hemihydrochloride) is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.

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Aminooxyacetic acid hemihydrochloride Chemical Structure
Aminooxyacetic acid hemihydrochloride, CAS 2921-14-4
Pack Size Availability Price/USD Quantity
500 mg In stock $ 41.00
1 g In stock $ 68.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Aminooxyacetic acid hemihydrochloride (Carboxymethoxylamine Hemihydrochloride) is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.
In vivo At various intervals after aminooxyacetic acid(AOAA) the rats were either injected with one of the convulsive drugs or sacrificed for analysis of the GABA concentration.?AOAA caused a rapid initial (0-30 min) and a later slower increase of GABA in cerebellum and whole brain.?In the synaptosomal fraction the GABA accumulation was delayed and less pronounced when compared to the whole brain.?The bicuculline induced convulsions were markedly potentiated during the first hour but completely blocked from 2-6 h after AOAA.?Picrotoxin showed a somewhat different pattern to bicuculline in the interactions with AOAA.?The initial strong potentiation was not observed but the later phase of protection was present.?In the interactions with 3-MPA, the effect of AOAA was always protective.?The time to onset of convulsions was gradually increased during the first 30 min after AOAA.?This protective effect remained practically unchanged up to 6 h after AOAA.?However, once started, the convulsions were generally of the same duration and intensity.?The results can be interpreted as GABA accumulating after AOAA stimulates GABA receptors to a degree more or less proportional to the whole brain GABA concentration and further that GABA synthetized in neurons is liberated, stimulates inhibitory bicuculline sensitive (predominant) and excitatory bicuculline insensitive receptors and is captured to a large extent by non-neuronal cells[1].
Synonyms Carboxymethoxylamine Hemihydrochloride
Molecular Weight 109.3
Formula NH2OCH2COOH·0.5HCl
CAS No. 2921-14-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 42.9 mg/mL (392.50 mM)

TargetMolReferences and Literature

1. Pagliusi S R , Gomes C , José R. Leite, et al. Aminooxyacetic acid induced accumulation of GABA in the rat brain[J]. Archiv für Experimentelle Pathologie und Pharmakologie, 1983, 322(3):210-215. 2. Korangath P , Teo W W , Sadik H , et al. Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate[J]. Clinical Cancer Research, 2015, 21(14):3263-3273.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Ion Channel Inhibitor Library Neuronal Signaling Compound Library Anti-Alzheimer's Disease Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Anti-Parkinson's Disease Compound Library Anti-Cancer Compound Library

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Keywords

Aminooxyacetic acid hemihydrochloride 2921-14-4 Membrane transporter/Ion channel Neuroscience Others GABA Receptor γ-Aminobutyric acid Receptor Aminooxyacetic acid Aminooxyacetate hemihydrochloride Inhibitor inhibit Carboxymethoxylamine Carboxymethoxylamine Hemihydrochloride Aminooxyacetic acid Hemihydrochloride Gamma-aminobutyric acid Receptor inhibitor

 

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