Endocrinology/Hormones Aromatase Aminoglutethimide


Catalog No. T1103   CAS 125-84-8
Synonyms: BA-16038, NSC-330915, DL-Aminoglutethimide

Aminoglutethimide, an aromatase inhibitor, is used in the therapy of advanced BREAST Y.

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Aminoglutethimide, CAS 125-84-8
Pack Size Availability Price/USD Quantity
25 mg In stock 54.00
50 mg In stock 82.00
100 mg In stock 142.00
200 mg In stock 181.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Purity 98.81%
Purity 99.95%
Biological Description
Chemical Properties
Storage & Solubility Information
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Description Aminoglutethimide, an aromatase inhibitor, is used in the therapy of advanced BREAST Y.
Targets&IC50 Aromatase
Kinase Assay Concentration–response and kinetic studies: The microsomal protein (30 μg), [1β-3H]androstenedione (6.6 × 105 dpm) and NADPH (270 μM) are used for the concentration–response experiment with an incubation time of 20 minutes. The Aminoglutethimide is initially tested at 10 μM and 100 μM concentrations, followed by a full concentration–response study with at least 8 concentrations ranging from 0.01 μM to 160 μM. For the initial velocity study the concentration of [1β-3H]androstenedione is varied from 7.5 to 100 nM and the incubation time is set to 5 minutes. The tritiated water formed during the conversion of the tritiated substrate, [1β-3H]androstenedione, to estrone is quantified by liquid scintillation counting. Each assay is performed three times in duplicate and the results are treated by nonlinear regression analysis allowing the determination of the half-maximal inhibitory concentration (IC50).
Cell Research
The NCI-h295 tumor cell line is maintained in RPMI 1640 medium supplemented with transferrin (0.1 mg/mL), insulin (5 μg/mL), selenium (5.2 μg/mL) and 2% FCS. The cells are incubated for 48 hours with Aminoglutethimide (3, 30, 300 μM). Then cells are examined by trypan blue staining for cell viability, counted with a coulter counter. For the assessment of ACTH-R mRNA, cells are harvested, and total RNA is extracted, electrophoresed, blotted and hybridized with a human ACTH-R cDNA probe.(Only for Reference)
Cell lines: Adrenocortical tumor cell line NCI-h295
Synonyms BA-16038 , NSC-330915 , DL-Aminoglutethimide
Purity 98.81%
Molecular Weight 232.28
Formula C13H16N2O2
CAS No. 125-84-8


Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 16 mg/mL (68.9 mM)

Ethanol: 7 mg/mL (30.13 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

1% DMSO+30% polyethylene glycol+1% Tween 80: 8 mg/mL


References and Literature
1. Neves MA, et al. Eur J Med Chem, 2009, 44(10), 4121-4127. 2. Fassnacht M, et al. J Endocrinol, 1998, 159(1), 35-42. 3. Santen RJ, et al. Cancer Res, 1982, 42(8 Suppl), 3353s-3359s. 4. Bastida CM, et al. Biochem Biophys Res Commun, 2001, 281(1), 244-248. 5. Kuma Y, et al. J Biol Chem. 2005, 280(20), 19472-19479.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-Cancer Compound Library Endocrinology-Hormone Compound Library FDA-Approved Drug Library Anti-Cancer Approved Drug Library Toxic Compound Library CNS-Penetrant Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Target-Focused Phenotypic Screening Library Drug-induced Liver Injury (DILI) Compound Library NMPA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Anti-Breast Cancer Compound Library

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