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Akt-I-1,2

Catalog No. T23695 CAS 473382-50-2

Akt-I-1,2 is a selective inhibitor of Akt1 and Akt2.

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Akt-I-1,2, CAS 473382-50-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 232.00
5 mg	In stock	$ 473.00
10 mg	In stock	$ 693.00
25 mg	In stock	$ 1,080.00
50 mg	In stock	$ 1,460.00
100 mg	In stock	$ 1,970.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Akt-I-1,2 is a selective inhibitor of Akt1 and Akt2.

Molecular Weight	375.89
Formula	C23H22ClN3
CAS No.	473382-50-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (13.3 mM)

References and Literature

1. Yamaji M, Ota A, Wahiduzzaman M, Karnan S, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Haniuda M. Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27. PubMed PMID: 28960945; PubMed Central PMCID: PMC5673922. 2. Liebl D, Qi X, Zhe Y, Barnett TC, Teasdale RD. SopB-Mediated Recruitment of SNX18 Facilitates Salmonella Typhimurium Internalization by the Host Cell. Front Cell Infect Microbiol. 2017 Jun 15;7:257. doi: 10.3389/fcimb.2017.00257. eCollection 2017. PubMed PMID: 28664153; PubMed Central PMCID: PMC5471308. 3. Zhang Q, Yang M, Qu Z, Zhou J, Jiang Q. Autophagy prevention sensitizes AKTi-1/2-induced anti-hepatocellular carcinoma cell activity in vitro and in vivo. Biochem Biophys Res Commun. 2016 Nov 18;480(3):334-340. doi: 10.1016/j.bbrc.2016.10.043. Epub 2016 Oct 15. PubMed PMID: 27756618. 4. Zhao QW, Zhou YW, Li WX, Kang B, Zhang XQ, Yang Y, Cheng J, Yin SY, Tong Y, He JQ, Yao HP, Zheng M, Wang YJ. Akt mediated phosphorylation of Oct4 is associated with the proliferation of stem like cancer cells. Oncol Rep. 2015 Apr;33(4):1621-9. doi: 10.3892/or.2015.3752. Epub 2015 Jan 27. PubMed PMID: 25625591; PubMed Central PMCID: PMC4358081.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Anti-Breast Cancer Compound Library Anti-Prostate Cancer Compound Library Anti-Obesity Compound Library Neuronal Differentiation Compound Library Anti-Colorectal Cancer Compound Library Antioxidant Compound Library Antidepressant Compound Library Glycolysis Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Akt-I-1,2 473382-50-2 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Akt AktI1,2 Akt I 1,2 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.