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AR-C155858

Catalog No. T14316 CAS 496791-37-8

AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM).

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AR-C155858, CAS 496791-37-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM).
Targets&IC50	MCT2:10 nM(ki), MCT1:(ki)2.3 nM
In vitro	AR-C155858 (10 nM-100 nM) inhibits MCT1/MCT2 C-terminal chimaeras[1]. AR-C155858 inhibits MCT1 expressed in Xenopus oocytes in a time- and concentration-dependent manner[2]. AR-C155858 inhibits MCT2, and the 70% inhibition seen at 10 nM is followed by a gradually increasing inhibition which can only be explained by a Ki value of significantly less than 10 nM.

Molecular Weight	461.54
Formula	C21H27N5O5S
CAS No.	496791-37-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 40 mg/mL (86.67 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ovens MJ, et al. The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein. Biochem J. 2010 Oct 15;431(2):217-25. 2. Ovens MJ, et al. AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem J. 2010 Jan 15;425(3):523-30. 3. Vijay N, et al. A Novel Monocarboxylate Transporter Inhibitor as a Potential Treatment Strategy for γ-Hydroxybutyric Acid Overdose. Pharm Res. 2015 Jun;32(6):1894-906.

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Keywords

AR-C155858 496791-37-8 离子通道 Monocarboxylate transporter inhibit Inhibitor Monocarboxylate Transporter AR-C-155858 ARC155858 AR C155858 inhibitor

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