Powder: -20°C for 3 years | In solvent: -80°C for 1 year
8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria, including vancomycin-resistant enterococci.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 91.00 | |
5 mg | In stock | $ 217.00 | |
10 mg | In stock | $ 320.00 | |
25 mg | In stock | $ 538.00 | |
50 mg | In stock | $ 779.00 | |
100 mg | In stock | $ 1,090.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 230.00 |
Description | 8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria, including vancomycin-resistant enterococci. |
In vitro | A novel plasmid-curing compound was identified as 8-Epidiosbulbin E acetate (EEA) (norditerpene) on the basis of modern spectroscopic analysis and X-ray crystallography. EEA exhibited broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria, including vancomycin-resistant enterococci. EEA cured antibiotic resistance plasmids (R-plasmids) from clinical isolates of Enterococcus faecalis, Escherichia coli, Shigella sonnei and Pseudomonas aeruginosa with 12-48% curing efficiency. The reference plasmids of Bacillus subtilis (pUB110), E. coli (RP4), P. aeruginosa (RIP64) and Salmonella typhi (R136) were cured with efficiency ranging from 16% to 64%. EEA-mediated R-plasmid curing decreased the minimal inhibitory concentration of antibiotics against MDR bacteria, thus making antibiotic treatment more effective. |
Source |
Molecular Weight | 388.41 |
Formula | C21H24O7 |
CAS No. | 91095-48-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (141.6 mM)
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8-Epidiosbulbin E acetate 91095-48-6 Microbiology/Virology Anti-infection Antibacterial Inhibitor 8Epidiosbulbin E acetate 8 Epidiosbulbin E acetate inhibit 8-Epidiosbulbin E Bacterial 8-Epidiosbulbin E Acetate inhibitor