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7-Epi 10-desacetyl paclitaxel

Catalog No. T5738 CAS 78454-17-8

Synonyms: 10-Deacetyl-7-epipaclitaxel, 7-Epi-10-deacetyltaxol

7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.

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7-Epi 10-desacetyl paclitaxel Chemical Structure

7-Epi 10-desacetyl paclitaxel, CAS 78454-17-8

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10 mg	In stock	$ 110.00

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Purity: 98.05%

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Description	7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.
In vitro	7-Epi-10-deacetyltaxol(EDT) exhibited significant in vitro cytotoxicity in HepG2 cells.Nuclear condensation and DNA fragmentation were observed in cells treated with fungal EDT.?Besides, the fungal EDT arrested HepG2 cells at G2/M phase of cell cycle.?Furthermore, fungal EDT induced apoptosis in HepG2 cells in a dose-dependent manner associated with ROS generation and increased Bax/Bcl-2 ratio, p38 MAPKs and PARP cleavage[1].
Cell Research	The endophytic fungus was identified by traditional and molecular taxonomical characterization and the fungal 7-Epi-10-deacetyltaxol(EDT) was purified using column chromatography and confirmed by various spectroscopic and chromatographic comparisons with authentic paclitaxel.?Studied the in vitro effects of EDT on HepG2 cells for parameters such as cell cycle distribution, DNA fragmentation, reactive oxygen species (ROS) generation and nuclear morphology.?Further, western blot analysis was used to evaluate Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), p38-mitogen activated protein kinase (MAPK) and poly [ADP-ribose] polymerase (PARP) expression[1].
Source	Natural Products > Taxaceae > Taxus

Synonyms	10-Deacetyl-7-epipaclitaxel, 7-Epi-10-deacetyltaxol
Molecular Weight	811.87
Formula	C45H49NO13
CAS No.	78454-17-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 8.11 mg/mL (9.99 mM)

References and Literature

1. Subban K , Singh S , Subramani R , et al. Fungal 7-epi-10-deacetyltaxol produced by an endophytic Pestalotiopsis microspora induces apoptosis in human hepatocellular carcinoma cell line (HepG2)[J]. BMC Complementary and Alternative Medicine, 2017, 17(1):504. 2. Dang P H , Nguyen H X , Duong T T T , et al. α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of\r, Taxus wallichiana[J]. Journal of Natural Products, 2017:acs.jnatprod.7b00006.

Related compound libraries

This product is contained In the following compound libraries：

Selected Plant-Sourced Compound Library Terpene Natural Product Library Tibetan medicine Compound Library NO PAINS Compound Library Natural Product Library Bioactive Compound Library Natural Product Library for HTS Bioactive Compounds Library Max Covalent Inhibitor Library

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Keywords

7-Epi 10-desacetyl paclitaxel 78454-17-8 Others 7Epi 10desacetyl paclitaxel 10-Deacetyl-7-epipaclitaxel 7-Epi-10-deacetyltaxol 7 Epi 10 desacetyl paclitaxel Inhibitor inhibit inhibitor

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