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3,6-Dihydroxyflavone

Catalog No. T7982   CAS 108238-41-1

3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway.

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3,6-Dihydroxyflavone Chemical Structure
3,6-Dihydroxyflavone, CAS 108238-41-1
Pack Size Availability Price/USD Quantity
10 mg In stock $ 66.00
100 mg In stock $ 320.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
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Purity: 99.95%
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Biological Description
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Storage & Solubility Information
Description 3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway.
In vitro 3,6-Dihydroxyflavone(3,6-DHF) could effectively inhibit EMT in BC cells in vitro and in vivo.?3,6-DHF effectively inhibits the formation and proliferation of BCSCs, and consequently reduces the tumor-initiating capacity of tumor cells in NOD/SCID mice.?Optical in vivo imaging of cancer metastasis showed that 3,6-DHF administration suppresses the lung metastasis of BC cells in vivo.?Further studies indicated that 3,6-DHF down-regulates Notch1, NICD, Hes-1 and c-Myc, consequently decreasing the formation of the functional transcriptional unit of NICD-CSL-MAML, causing Notch signaling inactivation in BC cells.?Over-expression of Notch1 or inhibition of miR-34a significantly reduced the inhibitory effects of 3,6-DHF on EMT, CSCs, as well as cells migration and invasion in BC cells[1].
Cell Research Cells were cultured in six-well plates until they reached 100% confluence. A vertical or horizontal wound was gently created in monolayers using a 20 μl sterile pipette tip. The cells were then washed for 3 times with growth medium to remove the detached cells, and the medium was added with fresh medium treated with 3,6-DHF. Images were captured using an inverted microscope and camera at designed times to assess the inhibition of wound closure[1].
Molecular Weight 254.24
Formula C15H10O4
CAS No. 108238-41-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (108.17 mM)

TargetMolReferences and Literature

1. Chen J , Chang H , Peng X , et al. 3,6-dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway[J]. Scientific Reports, 2016, 6:28858. 2. Voicescu M , Bandula R . 3,6-diHydroxyflavone/bovine serum albumin interaction in cyclodextrin medium: Absorption and emission monitoring[J]. Spectrochimica Acta Part A Molecular & Biomolecular Spectroscopy, 2015, 138:628-636.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Polyphenolic Natural Product Library Selected Plant-Sourced Compound Library RO5 Drug-like Natural Product Library Natural Product Library for HTS Bioactive Compounds Library Max Bioactive Compound Library NO PAINS Compound Library Flavonoid Natural Product Library Anti-Cancer Compound Library

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Keywords

3,6-Dihydroxyflavone 108238-41-1 Others inhibit Inhibitor caspase cascade cell viability oxidative stress 3,6-DHF Apoptosis PARP lipid peroxidation 3,6 Dihydroxyflavone 3,6Dihydroxyflavone inhibitor

 

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