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2'-MeCCPA

Catalog No. T22489 CAS 205171-12-6

Synonyms: 2-Chloro-N-cyclopentyl-2′-C-methyladenosine

2'-MeCCPA is a potent and highly selective A1 adenosine receptor (A1AR) agonist with a K-value of 1.8 nM for AR.2'-MeCCPA inhibits trichostatin-stimulated adenylate cyclase activity with an IC value of 13.1 nM.2'-MeCCPA exhibits analgesic activity and can be used in the study of HCV.

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2'-MeCCPA, CAS 205171-12-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 83.00
5 mg	In stock	$ 198.00
10 mg	In stock	$ 328.00
25 mg	In stock	$ 552.00
50 mg	In stock	$ 787.00
100 mg	In stock	$ 1,070.00
500 mg	In stock	$ 2,130.00

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Purity: 99.93%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	2'-MeCCPA is a potent and highly selective A1 adenosine receptor (A1AR) agonist with a K-value of 1.8 nM for AR.2'-MeCCPA inhibits trichostatin-stimulated adenylate cyclase activity with an IC value of 13.1 nM.2'-MeCCPA exhibits analgesic activity and can be used in the study of HCV.
In vivo	During reperfusion, 2'-MeCCPA (1 nM-1 M) significantly reduces the infarct area and risk ratio in male Sprague-Dawley rats[2].

Synonyms	2-Chloro-N-cyclopentyl-2′-C-methyladenosine
Molecular Weight	383.83
Formula	C16H22ClN5O4
CAS No.	205171-12-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (260.53 mM), Sonication is recommended.

References and Literature

1. Muntean BS, et al. Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits. Cell Rep. 2018 Jan 2;22(1):255-268. 2. J Bhandal, et al. Adenosine a1 receptor activation can protect the myocardium from ischaemia reperfusion injury post reperfusion. BMJ Journals. Volume 104, Issue Suppl 3.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library GPCR Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

2'-MeCCPA 205171-12-6 GPCR/G Protein Microbiology/Virology Neuroscience Proteases/Proteasome HCV Protease Adenosine Receptor 2-Chloro-N-cyclopentyl-2′-C-methyladenosine 2'MeCCPA 2' MeCCPA inhibitor inhibit

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