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Myriocin

Catalog No. T16165 CAS 35891-70-4

Myriocin is a fungal metabolite isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia. Myriocin also is an effective inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin strongly inhibits replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV. It has an IC50 of 3.5 μg/mL for inhibiting HCV infection.

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Myriocin, CAS 35891-70-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	401.54
Formula	C21H39NO6
CAS No.	35891-70-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 5 mg/mL (12.45 mM), ultrasonic and warming and heat to 60°C

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. He Q, et al. Inhibition of serine palmitoyltransferase by myriocin, a natural mycotoxin, causes inductionof c-myc in mouse liver. Mycopathologia. 2004 Apr;157(3):339-47. 2. Amemiya F, et al. Targeting lipid metabolism in the treatment of hepatitis C virus infection. J Infect Dis. 2008 Feb 1;197(3):361-70. 3. Ciesek S, et al. The suppressive effect that myriocin has on hepatitis C virus RNA replication is independent of inhibition of serine palmitoyl transferase. J Infect Dis. 2008 Oct 1;198(7):1091-3.

Related Products

Related compounds with same targets

Buddlejasaponin IV VER-00158411 SB-218078 Myriocin CCT244747 CHK-IN-1 CHK1 inhibitor CHK1-IN-4 hydrochloride

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Keywords

Myriocin 35891-70-4 细胞周期 Chk Inhibitor inhibitor inhibit

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