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18α-Glycyrrhetinic acid
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Catalog No. T2745Cas No. 1449-05-4
Alias Glycyrrhetinic acid, Enoxolone
18α-Glycyrrhetinic acid (Enoxolone) is an inhibitor of NF-kB and an activator of the proteasome, and functions as a longevity-promoting and anti-aggregation factor in multicellular organisms. It induces apoptosis.
18α-Glycyrrhetinic acid
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Purity: 99.68%
Catalog No. T2745Alias Glycyrrhetinic acid, EnoxoloneCas No. 1449-05-4
18α-Glycyrrhetinic acid (Enoxolone) is an inhibitor of NF-kB and an activator of the proteasome, and functions as a longevity-promoting and anti-aggregation factor in multicellular organisms. It induces apoptosis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $42 | In Stock | In Stock | |
| 50 mg | $66 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $46 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.68%
Appearance:Solid
Color:White
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Product Introduction
18α-Glycyrrhetinic acid AI Summary
18α-Glycyrrhetinic acid is a multifaceted biochemical agent demonstrating inhibition and cytotoxicity across a variety of assays and cell lines. It inhibits sodium fluorescein uptake by 47.07% in OATP1B1-transfected CHO cells and by 59.15% in OATP1B3-transfected CHO cells at an equimolar concentration of 10 µM. The compound shows antiviral activity against Influenza A virus A/WSN/33(H1N1) in MDCK cells, achieving 58.0% inhibition at 100 µM concentration. It also inhibits recombinant human PTP1B with an 81.0% inhibition rate at 25 µM concentration.
In cytotoxicity assays, 18α-Glycyrrhetinic acid maintains over 96.0% cell viability in mouse RAW264.7 cells at 40 µM after 24 hours. However, it exhibits considerable cytotoxic effects on various other cell lines, with IC50 values spanning from 63410.0 nM to 136400.0 nM, indicating potential anticancer properties. Additionally, the compound inhibits transglutaminase in human keratinocytes in the presence of retinal, demonstrating a range of inhibitory effects with activities from -0.3% to 225.0%. Lastly, 18α-Glycyrrhetinic acid acts as an inhibitor of the human 11beta-HSD1 enzyme, with IC50 values of 2214.0 nM and 2200.0 nM in HEK293 cell assays over a 10-minute measurement period..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 18α-Glycyrrhetinic acid (Enoxolone) is an inhibitor of NF-kB and an activator of the proteasome, and functions as a longevity-promoting and anti-aggregation factor in multicellular organisms. It induces apoptosis. |
| Synonyms | Glycyrrhetinic acid, Enoxolone |
| Molecular Weight | 470.68 |
| Formula | C30H46O4 |
| Cas No. | 1449-05-4 |
| Smiles | [H][C@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)C3CC[C@@]12C)C(O)=O |
| Relative Density. | 1.14g/cm3 |
| Storage | keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10.64 mg/mL (22.61 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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