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0990CL

Catalog No. T13983 CAS 511514-03-7

0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMP regulation. In the cell model, low concentration of 0990CL could partially restore cAMP level, and high concentration of 0990CL (10μM) began to have negative effects on cell viability.

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0990CL, CAS 511514-03-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 213.00
5 mg	In stock	$ 538.00
10 mg	In stock	$ 778.00
25 mg	In stock	$ 1,180.00
50 mg	In stock	$ 1,620.00
100 mg	In stock	$ 2,180.00
1 mL * 10 mM (in DMSO)	In stock	$ 563.00

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Purity: 98.86%

Biological Description

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Description

In vitro

0990CL (at a concentration of 30 μM with a 30-minute pre-treatment) exhibits preferential binding to Gαi1 compared to Gαq. It displays selectivity towards Gαi and Gαq, resulting in a maximum reduction of endpoint fluorescence by 38±8% and 10%, respectively. Treatment with 0990CL (100 nM to 1 μM , 24 h) restores α2AR/Gαi-mediated cAMP levels induced by Fsk and UK14304 in HEK293 GloSensor cells. At a dosage of 100 nM, it reinstates 31% of the reduced cAMP levels[1].

Molecular Weight	343.42
Formula	C21H21N5
CAS No.	511514-03-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.0 mg/mL (131.0 mM), Sonication is recommended.

References and Literature

1. Appleton KM,et al. Development of inhibitors of heterotrimeric Gαi subunits.Bioorg Med Chem. 2014 Jul 1;22(13):3423-3434.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Inhibitor Library GPCR Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

0990CL 511514-03-7 GPCR/G Protein Others cAMP inhibitor inhibit

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