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(S)-3-Hydroxyphenylglycine

Catalog No. T23291   CAS 71301-82-1

(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).

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(S)-3-Hydroxyphenylglycine Chemical Structure
(S)-3-Hydroxyphenylglycine, CAS 71301-82-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 128.00
5 mg In stock $ 263.00
10 mg In stock $ 375.00
25 mg In stock $ 629.00
50 mg In stock $ 898.00
100 mg In stock $ 1,230.00
500 mg In stock $ 2,460.00
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Purity: 99.18%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description (S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).
In vitro Hippocampal neurons in the slice preparation exhibit spontaneous synchronized bursting activity in the presence of picrotoxin, a γ-aminobutyric acid-A receptor antagonist. These synchronized bursts rarely exceed 500 ms in duration and thus resemble interictal discharges. Control shows one such synchronized burst, which typically consisted of an initial abrupt discharge 100–200 ms in duration (primary burst) followed by a series of briefer phasic discharges (secondary bursts). Addition of (S)-3-hydroxyphenylglycine (250–500 μM) significantly prolonged the synchronized burst duration, primarily via a marked increase in the number of secondary bursts. These prolonged discharges ranged from 1 to 7 s in duration (4,282 ± 1,060 ms, a 1,021?± 247% increase, n = 7), and the secondary bursts within each discharge gradually changed in amplitude and frequency[2].
Molecular Weight 167.16
Formula C8H9NO3
CAS No. 71301-82-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1.67 mg/mL (10 mM)

H2O: < 8.36 mg/mL

TargetMolReferences and Literature

1. Yu SP, Sensi SL, et al. Membrane-delimited modulation of NMDA currents by metabotropic glutamate receptor subtypes 1/5 in cultured mouse cortical neurons. J Physiol. 1997 Mar 15;499 ( Pt 3)(Pt 3):721-32. 2. Merlin LR, Wong RK. Role of group I metabotropic glutamate receptors in the patterning of epileptiform activities in vitro. J Neurophysiol. 1997 Jul;78(1):539-44.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Neuronal Signaling Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library

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Keywords

(S)-3-Hydroxyphenylglycine 71301-82-1 Neuroscience GluR (S) 3 Hydroxyphenylglycine 3-Hydroxyphenylglycine (S)3Hydroxyphenylglycine inhibitor inhibit

 

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