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(-)-Menthol

Catalog No. T1407 CAS 2216-51-5

Synonyms: L-Menthol, Levomenthol, Menthomenthol, Menthacamphor

(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foods, menthol functions as a fortifier for peppermint flavors. It also has a counterirritant effect on skin and mucous membranes, thereby producing a local analgesic or anesthetic effect.

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(-)-Menthol, CAS 2216-51-5

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500 mg	In stock	$ 46.00
1 g	In stock	$ 55.00
1 mL * 10 mM (in DMSO)	In stock	$ 51.00

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Purity: 99.01%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foods, menthol functions as a fortifier for peppermint flavors. It also has a counterirritant effect on skin and mucous membranes, thereby producing a local analgesic or anesthetic effect.
In vitro	(-)-Menthol induces cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dosedependent manner. (-)-Menthol inhibits the growth of rat liver epithelial tumor cells and acts as a potent chemopreventive agent during DMBA initiation of rat mammary tumors. (-)-menthol inhibits N-acetyltransferase activity. It also is found to inhibit the DNA topoisomerase I, II alpha and beta and to promote NF-kappaB expression in human gastric cancer SNU-5 cells. Additionally, (-)-menthol induces human promyelocytic leukemia HL-60 cell death through the Ca2+ release from the endoplasmic reticulum[1].
In vivo	The effects of (-)-menthol on WEHI-3 cells in vivo (BALB/c mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals. (-)-Menthol has been shown to be toxic in animals, but in humans, it is considered to be safe, with a small cardio-accelerating effect. At high doses (-)-menthol may exert a depressant effect on the central nervous system in rodents. (-)-menthol statistically decreases the weights of the liver and spleen in the examined animals and also decreases the percentage of MAC-3 and CD11b cells in the blood.[1].
Cell Research	Approximately 2x105 cells (WEHI-3) are incubated in 12-well plates containing medium for 24 h without (control) or with various concentrations (0, 25, 50, 75 and 100 μM) of (-)-menthol. The cells are harvested and washed with PBS before PI staining. The percentage of viable WEHI-3 cells is determined by trypan blue exclusion and flow cytometry. (Only for Reference)
Source	Natural Products > Lamiaceae > Mentha

Synonyms	L-Menthol, Levomenthol, Menthomenthol, Menthacamphor
Molecular Weight	156.27
Formula	C10H20O
CAS No.	2216-51-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 13 mg/mL (83.2 mM)

DMSO: 29 mg/mL (185.6 mM)

Ethanol: 29 mg/mL (185.6 mM)

References and Literature

1. Lu HF, et al. In Vivo. 2007, 21(2):285-9.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Cancer Drug Library GPCR Compound Library Tobacco Monomer Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Miao medicine Compound Library Gut Microbial Metabolite Library

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Keywords

(-)-Menthol 2216-51-5 Endocrinology/Hormones GPCR/G Protein Membrane transporter/Ion channel Metabolism Neuroscience Endogenous Metabolite TRP/TRPV Channel Opioid Receptor ()Menthol Inhibitor L-Menthol Transient receptor potential channels Levomenthol Menthol inhibit TRP Channel Menthomenthol Menthacamphor ( ) Menthol inhibitor

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