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(-)-Catechin gallate

Name: (-)-Catechin gallate
Brand: TargetMol
SKU: T3682
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3682Cas No. 130405-40-2

Alias (-)-Catechin 3-O-gallate, (-)-Catechin 3-gallate

(-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of 6PGD, IDH. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of human Beta-secretase. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) possesses antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 and chloroquine-resistant Plasmodium falciparum K1.

(-)-Catechin gallate

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🥰Excellent

Purity: 97.74%

Catalog No. T3682Alias (-)-Catechin 3-O-gallate, (-)-Catechin 3-gallateCas No. 130405-40-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	In Stock	In Stock
5 mg	$213	In Stock	In Stock
10 mg	$338	In Stock	In Stock
25 mg	$493	In Stock	In Stock
50 mg	$621	In Stock	In Stock
100 mg	$932	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.74%

Color:White to Red

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COA HNMR LCMS

Product Introduction

(-)-Catechin gallate AI Summary

(-)-Catechin gallate exhibits diverse bioactivities including inhibition of key enzymes and receptors. It inhibits human Beta-secretase 1 with an IC50 value of 6000.0 nM. Furthermore, it shows potent inhibition of FabZ, FabI, and FabG with respective IC50 values of 400.0 nM, 300.0 nM, and 1000.0 nM, demonstrating bioactivity in fatty acid biosynthesis pathways. The compound has notable antiplasmodial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains with IC50 values of 3200.0 nM and 400.0 nM, respectively. Additionally, (-)-Catechin gallate acts as an antagonist at human mu, delta, and kappa opioid receptors with Ke values of 210.0 nM, 950.0 nM, and 220.0 nM, respectively. It inhibits yeast G6PD, 6PGD, and IDH with IC50 values of 240.0 nM, 1280.0 nM, and 6620.0 nM, respectively, and shows an inhibitory IC50 of 25000.0 nM for G6PD-mediated NADPH production in mouse 3T3-L1 cells. Moreover, the compound inhibits the chymotrypsin-like activity of the purified human 20S proteasome with an IC50 value of 124.0 nM and inhibits duck liver FASN with an IC50 value of 3400.0 nM. It also exhibits antioxidant properties by inhibiting lipid peroxidation in a liposomal model. (-)-Catechin gallate shows inhibition of alpha-synuclein filament formation and SARS-CoV nucleocapsid protein with IC50 values of 21400.0 nM and 0.005 µg/mL, respectively. It inhibits PKM2 activity with an IC50 value of 850.0 nM and DYRK1A activity with an IC50 value of 220.0 nM. Finally, it inhibits SIRT6 deacetylase activity with an IC50 value of 2500.0 nM, demonstrating significant multi-target inhibitory characteristics..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of 6PGD, IDH. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of human Beta-secretase. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) possesses antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 and chloroquine-resistant Plasmodium falciparum K1.
Synonyms	(-)-Catechin 3-O-gallate, (-)-Catechin 3-gallate

Chemical Properties

Molecular Weight	442.37
Formula	C₂₂H₁₈O₁₀
Cas No.	130405-40-2
Smiles	Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H](Oc2c1)c1ccc(O)c(O)c1
Relative Density.	1.8 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (113.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2606 mL	11.3028 mL	22.6055 mL	113.0276 mL
5 mM	0.4521 mL	2.2606 mL	4.5211 mL	22.6055 mL
10 mM	0.2261 mL	1.1303 mL	2.2606 mL	11.3028 mL
20 mM	0.1130 mL	0.5651 mL	1.1303 mL	5.6514 mL
50 mM	0.0452 mL	0.2261 mL	0.4521 mL	2.2606 mL
100 mM	0.0226 mL	0.1130 mL	0.2261 mL	1.1303 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc